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MIRAGE

apelin receptor early endogenous ligand

Summary

Gene Symbol

APELA

Organism

Homo sapiens (human)

External Links

NCBI Gene

100506013

PubChem

100506013

Alliance of Genome Resources

HGNC:48925

Annotation

Keyword

3D-structure
Angiogenesis
Differentiation
Gastrulation
Glycoprotein
Hormone
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P0DMC3	Protein Elabela Protein Toddler
X5D2P3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
angiogenesis	IEA
vasculogenesis	ISS
G protein-coupled receptor signaling pathway	IDA	35817871
endoderm development	ISS
heart development	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

apelin receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesodermal cell migration [inference]

mesoderm migration involved in gastrulation

cell migration involved in gastrulation [inference]

multicellular organismal process [inference]

tissue migration [inference]

mesoderm migration involved in gastrulation

epithelium migration [inference]

mesendoderm migration

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

blood vessel development [inference]

tissue development [inference]

endoderm development

epithelium development [inference]

embryonic heart tube development

tube development [inference]

embryonic heart tube development

animal organ development [inference]

heart development

adult heart development

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of G protein-coupled receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

regulation of G protein-coupled receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

regulation of trophoblast cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

positive regulation of developmental process [inference]

positive regulation of trophoblast cell migration

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of trophoblast cell migration

positive regulation of blood circulation [inference]

positive regulation of heart contraction

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of reproductive process [inference]

positive regulation of trophoblast cell migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of G protein-coupled receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of trophoblast cell migration

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

apelin receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

regulation of G protein-coupled receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

regulation of G protein-coupled receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

regulation of receptor-mediated endocytosis [inference]

regulation of receptor internalization [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

regulation of G protein-coupled receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

positive regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor internalization [inference]

positive regulation of G protein-coupled receptor internalization

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

regulation of trophoblast cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

positive regulation of heart contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction

positive regulation of multicellular organismal process [inference]

positive regulation of trophoblast cell migration

positive regulation of blood circulation [inference]

positive regulation of heart contraction

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of reproductive process [inference]

regulation of trophoblast cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of reproductive process [inference]

positive regulation of trophoblast cell migration

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IDA	24316148 28137936
extracellular space	ISS
extracellular space	IDA	35817871

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hormone activity	ISS
hormone activity	IDA	35817871
hormone activity	IMP	25639753 28137936
apelin receptor binding	ISS
apelin receptor binding	IDA	28137936

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

neuropeptide receptor binding [inference]

apelin receptor binding

receptor ligand activity [inference]

hormone activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

apelin receptor early endogenous ligand

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
apelin receptor signaling pathway

Displaying 1 entry
InterPro
Apelin receptor early endogenous ligand

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	100038489		MOUSE58719
Ornithorhynchus anatinus	100078514		ORNAN04345
Xenopus tropicalis	100506013	Xenbase:XB-GENE-22067996
Pan troglodytes	100610777		PANTR34748
Pan paniscus	100972732		PANPA31233
Saimiri boliviensis boliviensis	101027838		SAIBB37073
Gorilla gorilla gorilla	101132396		GORGO30565
Bos taurus	101905445		BOVIN30982
Chinchilla lanigera	102013238		CHILA00668
Macaca fascicularis	102124850		MACFA34891

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Last updated: April 7, 2025