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ATP binding cassette subfamily C member 5

Summary

Gene Symbol

ABCC5

Organism

Homo sapiens (human)

External Links

NCBI Gene

10057

PubChem

10057

Alliance of Genome Resources

HGNC:56

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Endosome
Glycoprotein
Golgi apparatus
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
O15440	Multi-specific organic anion transporter C Multidrug resistance-associated protein 5 SMRP pABC11

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
export across plasma membrane	IDA	10840050
xenobiotic metabolic process	TAS
cAMP transport	IMP	10893247
transport across blood-brain barrier	NAS	26590417 30280653
purine nucleotide transport	IDA	10840050

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

cellular metabolic process [inference]

xenobiotic metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process [inference]

hyaluronan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

xenobiotic metabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

monoatomic anion transmembrane transport

glutathione transmembrane transport

vitamin transmembrane transport [inference]

folate transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

export across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

export from cell [inference]

export across plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

iron coordination entity transport [inference]

heme transport [inference]

heme transmembrane transport

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

monoatomic anion transport [inference]

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

monoatomic anion transmembrane transport

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport

xenobiotic transmembrane transport

vitamin transport [inference]

folic acid transport [inference]

folate transmembrane transport

vitamin transmembrane transport [inference]

folate transmembrane transport

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

monoatomic anion transmembrane transport

glutathione transmembrane transport

vitamin transmembrane transport [inference]

folate transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

iron ion transmembrane transport [inference]

heme transmembrane transport

export across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

glutathione transport [inference]

glutathione transmembrane transport

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport [inference]

folate transmembrane transport

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport

guanine nucleotide transport [inference]

cGMP transport

purine ribonucleotide transport [inference]

adenine nucleotide transport [inference]

cAMP transport

cyclic nucleotide transport [inference]

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport [inference]

folate transmembrane transport

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

heme transport [inference]

heme transmembrane transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport

guanine nucleotide transport [inference]

cGMP transport

purine ribonucleotide transport [inference]

adenine nucleotide transport [inference]

cAMP transport

cyclic nucleotide transport [inference]

modified amino acid transport [inference]

folic acid transport [inference]

folate transmembrane transport

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

nitrogen compound transport [inference]

heme transport [inference]

heme transmembrane transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport

guanine nucleotide transport [inference]

cGMP transport

purine ribonucleotide transport [inference]

adenine nucleotide transport [inference]

cAMP transport

cyclic nucleotide transport [inference]

amide transport [inference]

folic acid transport [inference]

folate transmembrane transport

modified amino acid transport [inference]

folic acid transport [inference]

folate transmembrane transport

export from cell [inference]

export across plasma membrane

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GO Term	Evidence Code	PMID
membrane	IBA IDA	15297306
Golgi lumen	IEA
apical plasma membrane	IDA	15501592 31791063
plasma membrane	IDA TAS	18619525 28112518
endosome membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

plasma membrane region [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
ABC-type xenobiotic transporter activity	IMP	12695538 15899835
ATP binding	IEA
efflux transmembrane transporter activity	IDA	10840050

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity

glutathione transmembrane transporter activity

heme transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

ATPase-coupled inorganic anion transmembrane transporter activity

efflux transmembrane transporter activity

organophosphate ester transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ATPase-coupled inorganic anion transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

macromolecule transmembrane transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

carbohydrate derivative transmembrane transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ATPase-coupled inorganic anion transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1793	pancreatic cancer	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 82 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Loxodonta africana	100673006		LOXAF11050
Oreochromis niloticus	100700437		ORENI16174
Cavia porcellus	100723026		CAVPO04521
Cricetulus griseus	100774121		CRIGR19542
Sarcophilus harrisii	100930016		SARHA08942
Otolemur garnettii	100966549		OTOGA00926
Pan paniscus	100981748	9597_0:00130a	PANPA29356
Papio anubis	101012670		PAPAN25390
Saimiri boliviensis boliviensis	101038841		SAIBB11758
Felis catus	101090542		FELCA22725

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements