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ATP binding cassette subfamily B member 1

Summary

Gene Symbol

Abcb1

Organism

Cricetulus griseus (Chinese hamster)

External Links

NCBI Gene: 100682536
PubChem: 100682536

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Cytoplasm
Glycoprotein
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P21448	ATP-binding cassette sub-family B member 1 Multidrug resistance protein 1 P-glycoprotein 1 Phospholipid transporter ABCB1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phospholipid translocation
terpenoid transport
transmembrane transport	IEA	22301074
xenobiotic detoxification by transmembrane export across the plasma membrane
xenobiotic transport across blood-brain barrier

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

xenobiotic transport [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

organic substance transport [inference]

lipid transport [inference]

phospholipid transport [inference]

phospholipid translocation

lipid translocation [inference]

phospholipid translocation

isoprenoid transport [inference]

terpenoid transport

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid translocation

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoplasm
membrane	IEA	22301074
apical plasma membrane
intercellular canaliculus

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

intercellular canaliculus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA	22301074
ABC-type xenobiotic transporter activity
ABC-type oligopeptide transporter activity
efflux transmembrane transporter activity
ATP hydrolysis activity	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phosphatidylcholine transporter activity [inference]

phosphatidylcholine floppase activity

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

sphingolipid transporter activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

transmembrane transporter activity [inference]

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity

ABC-type xenobiotic transporter activity

ABC-type peptide transporter activity [inference]

ABC-type oligopeptide transporter activity

amide transmembrane transporter activity [inference]

peptide transmembrane transporter activity [inference]

ABC-type peptide transporter activity [inference]

ABC-type oligopeptide transporter activity

oligopeptide transmembrane transporter activity [inference]

ABC-type oligopeptide transporter activity

xenobiotic transmembrane transporter activity [inference]

ABC-type xenobiotic transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity

ABC-type xenobiotic transporter activity

ABC-type peptide transporter activity [inference]

ABC-type oligopeptide transporter activity

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multidrug resistance

Functional Category

I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 7** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase
Type 1 protein exporter