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tetraspanin 5

Summary

Gene Symbol

TSPAN5

Organism

Homo sapiens (human)

External Links

NCBI Gene

10098

PubChem

10098

Alliance of Genome Resources

HGNC:17753

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P62079	Tetraspan NET-4 Transmembrane 4 superfamily member 9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
positive regulation of Notch signaling pathway	IMP	23091066
protein maturation	IMP	23091066
regulation of membrane protein ectodomain proteolysis	IDA	28600292 31792032
protein localization to plasma membrane	IMP	23091066

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation

cellular process [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

regulation of membrane protein ectodomain proteolysis

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of membrane protein ectodomain proteolysis

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

regulation of membrane protein ectodomain proteolysis

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

regulation of membrane protein ectodomain proteolysis

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

regulation of membrane protein ectodomain proteolysis

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of membrane protein ectodomain proteolysis

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	TAS
plasma membrane	IBA IDA TAS	23091066 31792032
nucleoplasm	IDA
actin cytoskeleton	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23091066 26686862 31792032 33961781
enzyme binding	IPI	23091066

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tetraspanin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Tetraspanin, EC2 domain superfamily
Tetraspanin, animals
Tetraspanin/Peripherin

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:162	cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	33838		FB:FBgn0031760
Mus musculus	56224		MGI:1928096	MOUSE38232
Caenorhabditis elegans	177890		WB:WBGene00006638
Rattus norvegicus	362048		RGD:1303176	RATNO25053
Xenopus laevis	399221		Xenbase:XB-GENE-6254205
Danio rerio	450026		ZFIN:ZDB-GENE-041010-145	DANRE41867
Pan troglodytes	461390	9598_0:001612		PANTR34155
Canis lupus familiaris	478486			CANLF13087
Danio rerio	494048		ZFIN:ZDB-GENE-041212-12
Bos taurus	538668			BOVIN31182