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sphingomyelin synthase 2

Summary

Gene Symbol

SGMS2

Organism

Ovis aries (sheep)

External Links

NCBI Gene: 101123121
KEGG Gene ID: oas:101123121
PubChem: 101123121

Annotation

Keyword

Reference proteome
Sphingolipid metabolism
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A6P3E6N4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
sphingomyelin biosynthetic process	IEA	30032202
ceramide biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

amide biosynthetic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA	30032202
Golgi membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
ceramide cholinephosphotransferase activity	IEA	30032202
sphingomyelin synthase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

phosphotransferase activity, for other substituted phosphate groups [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphatidylcholine:ceramide cholinephosphotransferase

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ceramide biosynthetic process
ceramide cholinephosphotransferase activity
phosphotransferase activity, for other substituted phosphate groups
sphingolipid metabolic process
sphingomyelin synthase activity
transferase activity

Displaying **all 2** entries
InterPro
Sphingomyelin synthase-like domain
Sphingomyelin synthase-like

KEGG BRITE Database

Orthology

K04714

Name

shingomyelin synthase [EC:2.7.8.27]

References

Ortholog

Displaying entries **21 - 30** of **109** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Loxodonta africana	100666455			LOXAF14223
Cavia porcellus	100715504			CAVPO16308
Cricetulus griseus	100760913			CRIGR19569
Sarcophilus harrisii	100933601			SARHA18300
Otolemur garnettii	100957457			OTOGA06502
Pan paniscus	100993903			PANPA30764
Papio anubis	101015814			PAPAN27649
Saimiri boliviensis boliviensis	101049165			SAIBB15885
Takifugu rubripes	101064260			TAKRU18041
Felis catus	101088574			FELCA08468

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024