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ALG3 alpha-1,3- mannosyltransferase

Summary

Gene Symbol

ALG3

Aliases

CDGS4
D16Ertd36e
NOT56L
Not56
carbohydrate deficient glycoprotein syndrome type IV
dol-P-Man dependent alpha-1,3- mannosyltransferase
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

10195

GGDB ID

gg144

HGNC

23056

mRNA

NM_005787

map

3q27.1

Protein

NP_005778

OMIM

608750

KEGG Gene ID

hsa:10195

PubChem

10195

Alliance of Genome Resources

HGNC:23056

Annotation

Keyword

Alternative splicing
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycosyltransferase
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92685	Asparagine-linked glycosylation protein 3 homolog Dol-P-Man-dependent alpha(1-3)-mannosyltransferase Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase Not56-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IDA	10581255
dolichol-linked oligosaccharide biosynthetic process	IDA TAS	10581255
protein glycosylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

isoprenoid metabolic process [inference]

polyprenol metabolic process [inference]

dolichol metabolic process [inference]

dolichol-linked oligosaccharide biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
lumenal side of endoplasmic reticulum membrane	IC	10581255
endoplasmic reticulum membrane	IDA TAS	10581255

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
alpha-1,3-mannosyltransferase activity	TAS
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity	IBA IDA	10581255
protein binding	IPI	21516116 25910212 29547901 31515488 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity [inference]

alpha-1,3-mannosyltransferase activity

dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000214160

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg144

Gene Symbol

ALG3

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
Dol-P-Man	G59406KS	G44865OQ

Displaying 1 entry
Donor	Acceptor	Product	Reference
Dol-P-Man	G59406KS	G44865OQ

Orthologous Gene

Displaying **all 6** entries
Species	Protein	mRNA
Arabidopsis thaliana	NP_182297	NM_130343
Saccharomyces cerevisiae	CAA84904	Z35844
Rattus norvegicus	XP_237830	XM_237830
Drosophila melanogaster	NP_523829	NM_079105
Caenorhabditis elegans	NP_496950	NM_064549
Mus musculus	NP_666051	NM_145939

KEGG BRITE Database

Orthology

K03845

Name

alpha-1,3-mannosyltransferase [EC:2.4.1.258]

References

18567790

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R06258	2.4.1.258	G59406KS G74840NI	G44865OQ

Disease

Disease Ontology

Displaying entries **1 - 10** of 30 in total

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DO ID	Disease Name	Source
DOID:0050570	congenital disorder of glycosylation type I	DisGeNET DisGeNET
DOID:0080087	nonsyndromic congenital nail disorder 9	DisGeNET
DOID:0080470	developmental and epileptic encephalopathy 36	DisGeNET
DOID:0080556	congenital disorder of glycosylation Id	Glyco-Disease Genes Database DisGeNET Alliance of Genome Resources
DOID:0080558	congenital disorder of glycosylation If	DisGeNET
DOID:10608	celiac disease	DisGeNET
DOID:10652	Alzheimer's disease	DisGeNET
DOID:10907	microcephaly	DisGeNET
DOID:11832	visual epilepsy	DisGeNET
DOID:11836	clubfoot	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000119	Abnormality of the genitourinary system
HP:0000158	Macroglossia
HP:0000172	Abnormal uvula morphology
HP:0000193	Bifid uvula
HP:0000218	High palate
HP:0000252	Microcephaly
HP:0000286	Epicanthus
HP:0000365	Hearing impairment
HP:0000366	Abnormality of the nose

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:79321	ALG3-congenital disorder of glycosylation
OMIM:601110	ALG3-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

ALG3-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Id; CDG1D

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012351
Gene Name: ALG3, alpha-1,3- mannosyltransferase

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175065	WB:WBGene00010720
Drosophila melanogaster	37754	FB:FBgn0011297
Callorhinchus milii	103182887		CALMI00490
Danio rerio	553725	ZFIN:ZDB-GENE-050522-334	DANRE29364
Astyanax mexicanus	103037087		ASTMX15117
Salmo salar	106600580		SALSA109401
Salmo trutta	115157451		SALTR61608
Salmo trutta	115169348		SALTR40353
Oryzias latipes	101167399		ORYLA06894
Sparus aurata	115572751		SPAAU38202

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements