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calcitonin receptor like receptor

Summary

Gene Symbol

CALCRL

Organism

Homo sapiens (human)

External Links

NCBI Gene

10203

PubChem

10203

Alliance of Genome Resources

HGNC:16709

Annotation

Keyword

3D-structure
Cell membrane
Direct protein sequencing
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q16602	Calcitonin receptor-like receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
calcitonin gene-related peptide receptor signaling pathway	IPI	10882736 9620797
receptor internalization	IDA	10882736 20074556
protein transport	IDA	9620797
heart development	IEA
cell surface receptor signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

calcitonin family receptor signaling pathway [inference]

cell population proliferation [inference]

muscle cell proliferation [inference]

smooth muscle cell proliferation [inference]

vascular associated smooth muscle cell proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

animal organ development [inference]

heart development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate [inference]

response to disaccharide [inference]

response to sucrose [inference]

cellular response to sucrose stimulus

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to disaccharide [inference]

response to sucrose [inference]

cellular response to sucrose stimulus

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to disaccharide stimulus [inference]

cellular response to sucrose stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

organic substance transport [inference]

nitrogen compound transport [inference]

protein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

establishment of protein localization [inference]

protein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

calcitonin family receptor signaling pathway [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA IDA TAS	10882736 18039931 9620797
endosome	IDA	10882736
adrenomedullin receptor complex	IDA IPI ISS	10882736 20074556 22102369 9620797
CGRP receptor complex	IDA	10882736 9620797
lysosome	IDA	10882736

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex [inference]

adrenomedullin receptor complex

calcitonin family receptor complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex [inference]

adrenomedullin receptor complex

calcitonin family receptor complex [inference]

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16293613 20596610 20826335 22102369 23597562 30115739 30209400 33602864
adrenomedullin binding	IPI	20074556 22102369
calcitonin receptor activity	IEA
calcitonin gene-related peptide receptor activity	IBA IPI	10882736 9620797
adrenomedullin receptor activity	IBA IPI	10882736 20074556 22102369 9620797

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

peptide hormone binding [inference]

calcitonin family binding [inference]

adrenomedullin binding

hormone binding [inference]

peptide hormone binding [inference]

calcitonin family binding [inference]

adrenomedullin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

calcitonin family receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity [inference]

calcitonin family receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Calcitonin gene-related peptide type 1 receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
calcitonin receptor activity
cell surface receptor signaling pathway

Displaying **all 6** entries
InterPro
GPCR family 2, extracellular hormone receptor domain superfamily
GPCR, family 2, calcitonin receptor family
GPCR, family 2, extracellular hormone receptor domain
GPCR, family 2, secretin-like, conserved site
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050580	hereditary lymphedema	Alliance of Genome Resources
DOID:3454	brain infarction	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	25029		RGD:2255	RATNO26095
Drosophila melanogaster	32246		FB:FBgn0030437
Drosophila melanogaster	36475		FB:FBgn0052843
Mus musculus	54598		MGI:1926944	MOUSE34067
Caenorhabditis elegans	175942		WB:WBGene00015735
Xenopus laevis	379898		Xenbase:XB-GENE-5736144
Sus scrofa	397172			PIGXX09626
Danio rerio	445508		ZFIN:ZDB-GENE-040822-26	DANRE44924
Pan troglodytes	459810	9598_0:000da1		PANTR29338
Canis lupus familiaris	488438			CANLF14040