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Guidelines

MIRAGE

ubiquitin specific peptidase like 1

Summary

Gene Symbol

USPL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10208

PubChem

10208

Alliance of Genome Resources

HGNC:20294

Annotation

Keyword

3D-structure
Alternative splicing
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Thiol protease

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A8K1B1
Q5W0Q7	Ubiquitin-specific peptidase-like protein 1
B3KQ64

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
proteolysis	IEA
cell population proliferation	IMP	22878415
snRNA transcription	IMP	24413172
protein desumoylation	IDA	22878415
protein desumoylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription

ncRNA transcription [inference]

snRNA transcription

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein desumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein desumoylation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription

ncRNA transcription [inference]

snRNA transcription

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription

ncRNA transcription [inference]

snRNA transcription

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription

ncRNA transcription [inference]

snRNA transcription

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription

ncRNA transcription [inference]

snRNA transcription

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein desumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein desumoylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein desumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein desumoylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein desumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein desumoylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription

ncRNA transcription [inference]

snRNA transcription

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription

ncRNA transcription [inference]

snRNA transcription

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein desumoylation

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein desumoylation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

cellular process [inference]

cell population proliferation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription

ncRNA transcription [inference]

snRNA transcription

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription

ncRNA transcription [inference]

snRNA transcription

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

ncRNA metabolic process [inference]

snRNA metabolic process [inference]

snRNA transcription

ncRNA transcription [inference]

snRNA transcription

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

ncRNA transcription [inference]

snRNA transcription

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

nucleus organization [inference]

nuclear body organization [inference]

Cajal body organization

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	HDA	22664934
Cajal body	IDA	22878415 24413172
Cajal body	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

nuclear body [inference]

Cajal body

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21988832 22878415 24413172 25416956 35914814
deSUMOylase activity	IDA	22878415
SUMO binding	IDA	22878415
SUMO binding	IBA
ubiquitin binding	IDA	22878415

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

deSUMOylase activity

ubiquitin-like protein peptidase activity [inference]

deSUMOylase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

deSUMOylase activity

ubiquitin-like protein peptidase activity [inference]

deSUMOylase activity

binding [inference]

protein binding

ubiquitin-like protein binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SUMO-specific isopeptidase USPL1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
Cajal body organization
SUMO binding

Displaying **all 5** entries
InterPro
Domain of unknown function DUF4650
Papain-like cysteine peptidase superfamily
USPL1 peptidase
Ubiquitin specific protease domain
Ubiquitin-specific peptidase-like, SUMO isopeptidase

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025