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steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

Summary

Gene Symbol

SRD5A1

Organism

Latimeria chalumnae (coelacanth)

External Links

NCBI Gene: 102346093
KEGG Gene ID: lcm:102346093
PubChem: 102346093

Annotation

Keyword

Reference proteome
Sexual differentiation
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
M3XJW8
H2ZXB2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
steroid metabolic process	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
membrane	IEA	22301074

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
3-oxo-5-alpha-steroid 4-dehydrogenase activity	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K12343

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 1 [EC:1.3.1.22]

References

2339109

Rhea

RHEA:54384

a 3-oxo-5α-steroid + NADP⁺

H⁺ + a 3-oxo-Δ⁴-steroid + NADPH

Enzyme

1.3.1.22

PMID

RHEA:21952

5α-pregnane-3,20-dione + NADP⁺

H⁺ + progesterone + NADPH

Enzyme

1.3.1.22

PMID

RHEA:50820

17β-hydroxy-5α-androstan-3-one + NADP⁺

H⁺ + testosterone + NADPH

Enzyme

1.3.1.22

PMID

Ortholog

Displaying entries **71 - 72** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Carlito syrichta	103257156		CARSF19321
Strigops habroptila	115617808		STRHB14955

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements