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leucyl-tRNA synthetase, mitochondrial

Summary

Gene Symbol

Lars2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

102436

PubChem

102436

Alliance of Genome Resources

MGI:2142973

Annotation

Keyword

ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Mitochondrion
Protein biosynthesis
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8VDC0	Leucyl-tRNA synthetase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrial translation	IBA
leucyl-tRNA aminoacylation	IBA IEA ISO
aminoacyl-tRNA metabolism involved in translational fidelity	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

protein metabolic process [inference]

translation [inference]

mitochondrial translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

protein metabolic process [inference]

translation [inference]

mitochondrial translation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

protein metabolic process [inference]

translation [inference]

mitochondrial translation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

protein metabolic process [inference]

translation [inference]

mitochondrial translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation [inference]

mitochondrial translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation [inference]

mitochondrial translation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation [inference]

leucyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

biological regulation [inference]

regulation of biological quality [inference]

regulation of translational fidelity [inference]

aminoacyl-tRNA metabolism involved in translational fidelity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	HDA IBA	14651853 18614015
mitochondrial matrix	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
aminoacyl-tRNA editing activity	IEA
leucine-tRNA ligase activity	IBA IEA ISO
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

aminoacyl-tRNA editing activity

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity [inference]

leucine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA editing activity

aminoacyl-tRNA ligase activity [inference]

leucine-tRNA ligase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

leucine--tRNA ligase, mitochondrial

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis

Displaying **all 9** entries
Gene Ontology
ATP binding
aminoacyl-tRNA editing activity
aminoacyl-tRNA metabolism involved in translational fidelity
leucine-tRNA ligase activity
leucyl-tRNA aminoacylation
ligase activity
mitochondrial translation
nucleotide binding
tRNA aminoacylation for protein translation

Displaying **all 8** entries
InterPro
Aminoacyl-tRNA synthetase, class I, conserved site
Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Aminoacyl-tRNA synthetase, class Ia
Leucine-tRNA ligase
Leucyl-tRNA synthetase, editing domain
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
Rossmann-like alpha/beta/alpha sandwich fold
Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050857	Perrault syndrome	Alliance of Genome Resources
DOID:700	mitochondrial metabolism disease	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **114** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Ornithorhynchus anatinus	100082885			ORNAN26343
Danio rerio	100126021		ZFIN:ZDB-GENE-070928-3	DANRE10131
Pongo abelii	100174294			PONAB25282
Taeniopygia guttata	100231172			TAEGU18644
Oryctolagus cuniculus	100358356			RABIT12745
Xenopus tropicalis	100379697		Xenbase:XB-GENE-956205
Callithrix jacchus	100394551			CALJA11611
Ailuropoda melanoleuca	100484574			AILME19335
Sus scrofa	100513625			PIGXX03902
Meleagris gallopavo	100540484			MELGA11726

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Last updated: December 9, 2024