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ATP binding cassette subfamily C member 4 (PEL blood group)

Summary

Gene Symbol

ABCC4

Organism

Homo sapiens (human)

External Links

NCBI Gene

10257

PubChem

10257

Alliance of Genome Resources

HGNC:55

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Glycoprotein
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K2Q2
O15439	MRP/cMOAT-related ABC transporter Multi-specific organic anion transporter B Multidrug resistance-associated protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
platelet degranulation	TAS
xenobiotic metabolic process	TAS
xenobiotic transmembrane transport	TAS
bile acid and bile salt transport	IMP	16282361
prostaglandin transport	IMP	15364914

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

xenobiotic metabolic process

cellular process [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

cellular metabolic process [inference]

xenobiotic metabolic process

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

glutathione transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport

export across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

signal release [inference]

prostaglandin secretion

export across plasma membrane

lipid export from cell [inference]

prostaglandin secretion

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

vascular transport [inference]

transport across blood-brain barrier

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

xenobiotic transport [inference]

xenobiotic transmembrane transport

secretion [inference]

icosanoid secretion [inference]

prostaglandin secretion

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

signal release [inference]

prostaglandin secretion

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

glutathione transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport

export across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport

organic substance transport [inference]

lipid transport [inference]

bile acid and bile salt transport

fatty acid transport [inference]

prostaglandin transport

prostaglandin secretion

lipid export from cell [inference]

prostaglandin secretion

organic anion transport [inference]

urate transport

glutathione transport [inference]

glutathione transmembrane transport

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

fatty acid transport [inference]

prostaglandin transport

prostaglandin secretion

icosanoid transport [inference]

prostaglandin transport

prostaglandin secretion

icosanoid secretion [inference]

prostaglandin secretion

leukotriene transport

cAMP transport

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport

purine ribonucleotide transport [inference]

cAMP transport

adenine nucleotide transport [inference]

cAMP transport

cyclic nucleotide transport [inference]

cAMP transport

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

fatty acid transport [inference]

prostaglandin transport

prostaglandin secretion

icosanoid transport [inference]

prostaglandin transport

prostaglandin secretion

icosanoid secretion [inference]

prostaglandin secretion

leukotriene transport

organic hydroxy compound transport [inference]

bile acid and bile salt transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport

purine ribonucleotide transport [inference]

cAMP transport

adenine nucleotide transport [inference]

cAMP transport

cyclic nucleotide transport [inference]

cAMP transport

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

cAMP transport

nitrogen compound transport [inference]

urate transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport

purine ribonucleotide transport [inference]

cAMP transport

adenine nucleotide transport [inference]

cAMP transport

cyclic nucleotide transport [inference]

cAMP transport

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

signal release [inference]

prostaglandin secretion

export across plasma membrane

lipid export from cell [inference]

prostaglandin secretion

establishment of localization in cell [inference]

platelet degranulation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleolus	IDA
Golgi apparatus	IDA
plasma membrane	TAS
plasma membrane	IDA	15297306 18619525 23137377 25173977 28112518
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

platelet dense granule membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

platelet dense granule membrane

plasma membrane region [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

intracellular non-membrane-bounded organelle [inference]

nucleolus

side of membrane [inference]

external side of plasma membrane [inference]

external side of apical plasma membrane

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
guanine nucleotide transmembrane transporter activity	IDA	15454390
protein binding	IPI	22411990 29146910
ATP binding	IEA
ABC-type xenobiotic transporter activity	IEA
prostaglandin transmembrane transporter activity	IMP	15364914

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

15-hydroxyprostaglandin dehydrogenase (NAD+) activity

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

bile acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

icosanoid transmembrane transporter activity [inference]

prostaglandin transmembrane transporter activity

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

ATPase-coupled organic acid transmembrane transporter activity [inference]

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

organic anion transmembrane transporter activity [inference]

glutathione transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

bile acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

ATPase-coupled inorganic anion transmembrane transporter activity

efflux transmembrane transporter activity

organophosphate ester transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity

guanine nucleotide transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity

guanine nucleotide transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ATPase-coupled organic acid transmembrane transporter activity [inference]

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled inorganic anion transmembrane transporter activity

ABC-type transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

icosanoid transmembrane transporter activity [inference]

prostaglandin transmembrane transporter activity

organic hydroxy compound transmembrane transporter activity [inference]

bile acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

sulfur compound transmembrane transporter activity [inference]

ABC-type glutathione S-conjugate transporter activity

salt transmembrane transporter activity [inference]

urate transmembrane transporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ATPase-coupled organic acid transmembrane transporter activity [inference]

ATPase-coupled carboxylic acid transmembrane transporter activity [inference]

ATPase-coupled monocarboxylic acid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled lipid transmembrane transporter activity [inference]

ABC-type bile acid transporter activity

ATPase-coupled inorganic anion transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10257	Xenbase:XB-GENE-957302
Xenopus tropicalis	47905	Xenbase:XB-GENE-957302
Rattus norvegicus	170924		RATNO10105
Mus musculus	239273		MOUSE12678
Pan troglodytes	452625		PANTR07960
Canis lupus familiaris	485523		CANLF08795
Bos taurus	515333		BOVIN04013
Drosophila melanogaster	559080	FB:FBgn0010549
Macaca mulatta	695407		MACMU16844
Xenopus tropicalis	853198	Xenbase:XB-GENE-957302

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