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splicing factor 3b subunit 4

Summary

Gene Symbol

SF3B4

Organism

Homo sapiens (human)

External Links

NCBI Gene

10262

PubChem

10262

Alliance of Genome Resources

HGNC:10771

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repeat
Spliceosome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B3KUJ0
Q15427	Pre-mRNA-splicing factor SF3b 49 kDa subunit Spliceosome-associated protein 49

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
RNA splicing, via transesterification reactions	TAS	7958871
mRNA splicing, via spliceosome	NAS	31744343
mRNA splicing, via spliceosome	IC	9731529
mRNA splicing, via spliceosome	IDA	27720643 29360106 32494006 36797247
mRNA splicing, via spliceosome	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal complex assembly [inference]

U2-type prespliceosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal complex assembly [inference]

U2-type prespliceosome assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

spliceosomal complex assembly [inference]

U2-type prespliceosome assembly

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleus	NAS	31744343
nucleus	IDA	27720643 28541300 29360106
nucleoplasm	TAS
spliceosomal complex	NAS	31744343
spliceosomal complex	IDA	9731529

GO Hierarchy

cellular component

protein-containing complex [inference]

Sm-like protein family complex [inference]

small nuclear ribonucleoprotein complex [inference]

spliceosomal snRNP complex [inference]

U2 snRNP

nuclear protein-containing complex [inference]

spliceosomal complex

U2-type spliceosomal complex

U2-type precatalytic spliceosome

U12-type spliceosomal complex

precatalytic spliceosome

U2-type precatalytic spliceosome

small nuclear ribonucleoprotein complex [inference]

spliceosomal snRNP complex [inference]

U2 snRNP

ribonucleoprotein complex [inference]

spliceosomal complex

U2-type spliceosomal complex

U2-type precatalytic spliceosome

U12-type spliceosomal complex

precatalytic spliceosome

U2-type precatalytic spliceosome

small nuclear ribonucleoprotein complex [inference]

spliceosomal snRNP complex [inference]

U2 snRNP

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
RNA binding	IBA
RNA binding	HDA	22658674 22681889
protein binding	IPI	15105431 16189514 17332742 17474147 21516116 21988832 22365833 25416956 25737013 26871637 27905398 29892012 31515488 32296183 35271311 36217029 39251607
splicing factor binding	IDA	27720643 28541300

GO Hierarchy

molecular function

binding [inference]

protein binding

splicing factor binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

subunit 4 of splicing factor 3B

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
InterPro
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily
SF3B4, RNA recognition motif 1
SF3B4, RNA recognition motif 2

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:4362	cervical cancer	Alliance of Genome Resources
DOID:5768	Nager acrofacial dysostosis	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 75 in total

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Species	Gene ID	Orthologous MAtrix
Cricetulus griseus	100759502	CRIGR05034
Otolemur garnettii	100956651	OTOGA03126
Pan paniscus	100984787	PANPA02314
Papio anubis	101009249	PAPAN19528
Takifugu rubripes	101073684	TAKRU05846
Felis catus	101081822	FELCA18807
Ovis aries	101101849	SHEEP00771
Gorilla gorilla gorilla	101127176	GORGO21631
Tursiops truncatus	101319278	TURTR06499
Mustela putorius furo	101682968	MUSPF03032