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hydroxyacylglutathione hydrolase

Summary

Gene Symbol

HAGH

Organism

Leptonychotes weddellii (Weddell seal)

External Links

NCBI Gene: 102732496
KEGG Gene ID: lww:102732496
PubChem: 102732496

Annotation

Keyword

Hydrolase
Metal-binding
Mitochondrion
Reference proteome
Transit peptide
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2U3YE61	Glyoxalase II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	IEA	22301074
glutathione metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

small molecule catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic substance catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular ketone metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular ketone metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

small molecule catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

glutathione metabolic process

cellular ketone metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic substance catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic hydroxy compound metabolic process [inference]

lactate metabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

lactate metabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular ketone metabolic process [inference]

methylglyoxal metabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

cellular catabolic process [inference]

ketone catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

aldehyde catabolic process [inference]

methylglyoxal catabolic process [inference]

methylglyoxal catabolic process to lactate [inference]

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying 1 entry
GO Term	Evidence Code	PMID
hydroxyacylglutathione hydrolase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

hydroxyacylglutathione hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:25245

H₂O + (R)-S-lactoylglutathione

H⁺ + (R)-lactate + glutathione

Enzyme

3.1.2.6

PMID

RHEA:21864

H₂O + an S-(2-hydroxyacyl)glutathione

H⁺ + glutathione + a 2-hydroxy carboxylate

Enzyme

3.1.2.6

PMID

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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