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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Summary

Gene Symbol

B3GNT3

Aliases

B3GN-T3
B3GNT-3
HP10328
beta-1,3-N-acetylglucosaminyltransferase bGnT-3
beta3Gn-T3
putative type II membrane protein
transmembrane protein 3

Organism

Homo sapiens (human)

External Links

NCBI Gene

10331

GGDB ID

gg117

HGNC

13528

mRNA

NM_014256

map

19p13.1

Protein

NP_055071

OMIM

605863

KEGG Gene ID

hsa:10331

PubChem

10331

Alliance of Genome Resources

HGNC:13528

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y2A9	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase Beta-1,3-galactosyltransferase 8 Beta-3-Gx-T8 Core 1 extending beta-1,3-N-acetylglucosaminyltransferase Core1-beta3GlcNAcT Transmembrane protein 3 UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein O-linked glycosylation	IBA
poly-N-acetyllactosamine biosynthetic process	IBA IDA	11042166
keratan sulfate biosynthetic process	TAS
O-glycan processing	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS	10072769
Golgi membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	IBA IDA IEA TAS	11042166
beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	TAS
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

beta-1,3-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000179913

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg117

Gene Symbol

B3GNT3

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G00031MO	G75472OU	11439191

Displaying **all 8** entries
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G84224TW	G06239NA	11042166 11439191
UDP-GlcNAc	G00031MO	G75472OU	11439191
UDP-GlcNAc	G00049MO	G97033IB	11042166
UDP-GlcNAc	G60629OV
UDP-GlcNAc	G00033MO	G68893BQ	11439191
UDP-GlcNAc	G72002FC
UDP-GlcNAc	G58896AZ	G70874WW	11042166
UDP-GlcNAc	G78941GA	G68257ZA	11042166

Displaying **all 3** entries
Donor	Acceptor	Reference
UDP-GlcNAc	G26123AX	11042166
UDP-GlcNAc	G00055MO	11042166
UDP-GlcNAc	G65889KE	11439191

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Arabidopsis thaliana	NP_177618	NM_106138
Rattus norvegicus	XP_224719	XM_224719
Mus musculus	NP_082465	NM_028189

KEGG BRITE Database

Orthology

K07970

Name

beta-1,3-N-acetylglucosaminyltransferase 3 [EC:2.4.1.146 2.4.1.149]

References

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05974	2.4.1.149	G84034JH	G91404LJ
R05901	2.4.1.146	G00033MO	G27236KE
R05975	2.4.1.149	G58896AZ	G70874WW

Rhea

RHEA:56224

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.146

PMID

RHEA:14389

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + UDP-N-acetyl-α-D-glucosamine

an N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.149

PMID

RHEA:56220

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.146

PMID

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:11165	common wart	DisGeNET
DOID:1324	lung cancer	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:2893	cervix carcinoma	DisGeNET DisGeNET
DOID:3702	cervical adenocarcinoma	DisGeNET
DOID:3908	lung non-small cell carcinoma	DisGeNET
DOID:4362	cervical cancer	DisGeNET DisGeNET DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:769	neuroblastoma	DisGeNET DisGeNET
DOID:8469	influenza	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001971
Gene Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Ortholog

Displaying entries **1 - 10** of **104** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178142	WB:WBGene00000270
Drosophila melanogaster	31358	FB:FBgn0000221
Latimeria chalumnae	102345207		LATCH00053
Danio rerio	494166	ZFIN:ZDB-GENE-040625-129	DANRE42544
Danio rerio	561028	ZFIN:ZDB-GENE-081105-12	DANRE42578
Danio rerio	561172	ZFIN:ZDB-GENE-030131-8875	DANRE42585
Danio rerio	100002020	ZFIN:ZDB-GENE-081104-528	DANRE42568
Astyanax mexicanus	103026573		ASTMX02055
Ictalurus punctatus	108265513		ICTPU30460
Electrophorus electricus	113587291		ELEEL38748

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements