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C-type lectin domain family 4 member M

Summary

Gene Symbol

CLEC4M

Organism

Homo sapiens (human)

External Links

NCBI Gene

10332

PubChem

10332

Alliance of Genome Resources

HGNC:13523

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Calcium
Cell membrane
Disulfide bond
Endocytosis
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Innate immunity
Mannose-binding
Metal-binding
Reference proteome
Repeat
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H2X3	CD209 antigen-like protein 1 DC-SIGN-related protein Dendritic cell-specific ICAM-3-grabbing non-integrin 2 Liver/lymph node-specific ICAM-3-grabbing non-integrin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
receptor-mediated virion attachment to host cell	IDA	15479853 32766577
peptide antigen transport	NAS	11337487
virion attachment to host cell	TAS	11337487
viral genome replication	NAS	11337487
receptor-mediated endocytosis of virus by host cell	NAS	15479853 32766577

GO Hierarchy

biological process

immune system process [inference]

immune response

antigen processing and presentation

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

leukocyte cell-cell adhesion

signal transduction [inference]

intracellular signal transduction

cell recognition [inference]

cell-cell recognition

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

viral process [inference]

viral genome replication

transport of virus [inference]

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

intracellular transport of virus

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell

receptor-mediated virion attachment to host cell

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

organic substance transport [inference]

peptide transport [inference]

peptide antigen transport

nitrogen compound transport [inference]

amide transport [inference]

peptide transport [inference]

peptide antigen transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

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GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
membrane	TAS	11337487
host cell	IEA
plasma membrane	TAS
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

host cellular component [inference]

host cell

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	32296183 32607506 32766577 33961781 34015061 34341769
metal ion binding	IEA
calcium-dependent protein binding	IPI	12609975
mannose binding	IBA
ICAM-3 receptor activity	NAS	11257134

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

calcium-dependent protein binding

exogenous protein binding [inference]

virus receptor activity

carbohydrate binding

monosaccharide binding [inference]

mannose binding

amide binding [inference]

peptide binding [inference]

peptide antigen binding

small molecule binding [inference]

monosaccharide binding [inference]

mannose binding

ion binding [inference]

cation binding [inference]

metal ion binding

virion binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

ICAM-3 receptor activity

pattern recognition receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-type lectin-like

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
U: Intracellular trafficking, secretion, and vesicular transport

Displaying **all 3** entries
Gene Ontology
adaptive immune response
fucose binding
mannose binding

Displaying **all 5** entries
InterPro
C-type lectin fold
C-type lectin, conserved site
C-type lectin-like/link domain superfamily
C-type lectin-like
CD209-like, C-type lectin-like domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050598	extrapulmonary tuberculosis	Alliance of Genome Resources
DOID:2945	severe acute respiratory syndrome	Alliance of Genome Resources
DOID:2957	pulmonary tuberculosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 13 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	53516		FB:FBgn0040096
Mus musculus	69165		MGI:1916415	MOUSE59394
Mus musculus	170786		MGI:2157942
Rattus norvegicus	288378		RGD:1561466	RATNO05466
Pan troglodytes	455661	9598_0:004cbd		PANTR17010
Danio rerio	564690		ZFIN:ZDB-GENE-080204-76
Pongo abelii	100460339	9601_0:004aca
Nomascus leucogenys	100605870			NOMLE00762
Cricetulus griseus	100773525			CRIGR17132
Pan paniscus	100978434	9597_0:004b36

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements