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C-type lectin domain family 4 member M

Summary

Gene Symbol

CLEC4M

Organism

Homo sapiens (human)

External Links

NCBI Gene

10332

PubChem

10332

Alliance of Genome Resources

HGNC:13523

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Calcium
Cell membrane
Disulfide bond
Endocytosis
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Innate immunity
Mannose-binding
Metal-binding
Reference proteome
Repeat
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H2X3	CD209 antigen-like protein 1 DC-SIGN-related protein Dendritic cell-specific ICAM-3-grabbing non-integrin 2 Liver/lymph node-specific ICAM-3-grabbing non-integrin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
receptor-mediated virion attachment to host cell	IDA	15479853 32766577
peptide antigen transport	NAS	11337487
virion attachment to host cell	TAS	11337487
viral genome replication	NAS	11337487
receptor-mediated endocytosis of virus by host cell	NAS	15479853 32766577

GO Hierarchy

biological process

immune system process [inference]

immune response

antigen processing and presentation

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

leukocyte cell-cell adhesion

signal transduction [inference]

intracellular signal transduction

cell recognition [inference]

cell-cell recognition

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

viral process [inference]

viral genome replication

transport of virus [inference]

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

intracellular transport of virus

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell

receptor-mediated virion attachment to host cell

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

organic substance transport [inference]

peptide transport [inference]

peptide antigen transport

nitrogen compound transport [inference]

amide transport [inference]

peptide transport [inference]

peptide antigen transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
membrane	TAS	11337487
host cell	IEA
plasma membrane	TAS
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

host cellular component [inference]

host cell

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
signaling receptor activity	NAS	11257134
virion binding	TAS	11337487
pattern recognition receptor activity	IBA
virus receptor activity	IDA IMP	15496474 24623090
peptide antigen binding	NAS	11337487

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

calcium-dependent protein binding

exogenous protein binding [inference]

virus receptor activity

carbohydrate binding

monosaccharide binding [inference]

mannose binding

amide binding [inference]

peptide binding [inference]

peptide antigen binding

small molecule binding [inference]

monosaccharide binding [inference]

mannose binding

ion binding [inference]

cation binding [inference]

metal ion binding

virion binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

ICAM-3 receptor activity

pattern recognition receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-type lectin-like

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
U: Intracellular trafficking, secretion, and vesicular transport

Displaying **all 3** entries
Gene Ontology
adaptive immune response
fucose binding
mannose binding

Displaying **all 5** entries
InterPro
C-type lectin fold
C-type lectin, conserved site
C-type lectin-like/link domain superfamily
C-type lectin-like
CD209-like, C-type lectin-like domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050598	extrapulmonary tuberculosis	Alliance of Genome Resources
DOID:2945	severe acute respiratory syndrome	Alliance of Genome Resources
DOID:2957	pulmonary tuberculosis	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 13** of 13 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Gorilla gorilla gorilla	101152880	9595_0:005005		GORGO14791
Xenopus laevis	108711688		Xenbase:XB-GENE-17340322
Pongo pygmaeus	129020765	9600_0:0049be

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements