GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Methyltransferase
Mitochondrion
Phospholipid biosynthesis
Reference proteome
S-adenosyl-L-methionine
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UBM1	PEMT2 Phospholipid methyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
sphingomyelin biosynthetic process	IEA
phosphatidylcholine biosynthetic process	IBA IEA TAS
blastocyst hatching	IEA
positive regulation of cold-induced thermogenesis	ISS	26113536
methylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

amide metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

methylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingomyelin biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin biosynthetic process

phospholipid biosynthetic process [inference]

sphingomyelin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

multicellular organismal process [inference]

organism emergence from protective structure [inference]

hatching [inference]

blastocyst hatching

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrial membrane	IEA
endoplasmic reticulum membrane
intracellular membrane-bounded organelle	IDA
mitochondrion	IDA
endoplasmic reticulum	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
phosphatidyl-N-methylethanolamine N-methyltransferase activity	IEA
phosphatidylethanolamine N-methyltransferase activity	IBA TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

N-methyltransferase activity [inference]

S-adenosylmethionine-dependent methyltransferase activity [inference]

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphatidyl-N-methylethanolamine N-methyltransferase

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 9** entries
Gene Ontology
S-adenosylmethionine-dependent methyltransferase activity
lipid metabolic process
methylation
phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
phosphatidyl-N-methylethanolamine N-methyltransferase activity
phosphatidylcholine biosynthetic process
phosphatidylethanolamine N-methyltransferase activity
phospholipid biosynthetic process
transferase activity

Displaying **all 2** entries
InterPro
Phosphatidyl-N-methylethanolamine/Phosphatidylethanolamine N-methyltransferase
Phospholipid methyltransferase

Rhea

RHEA:11164

S-adenosyl-L-methionine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine

H⁺ + S-adenosyl-L-homocysteine + 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine

Enzyme

2.1.1.17

PMID

RHEA:32739

S-adenosyl-L-methionine + 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine

H⁺ + a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine

Enzyme

2.1.1.71

PMID

RHEA:32735

S-adenosyl-L-methionine + 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine

H⁺ + S-adenosyl-L-homocysteine + 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine

Enzyme

2.1.1.71

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002703
Gene Name: phosphatidylethanolamine N-methyltransferase

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18618		MGI:104535	MOUSE03614
Rattus norvegicus	25511		RGD:3297	RATNO00501
Bos taurus	360197			BOVIN12991
Danio rerio	393127		ZFIN:ZDB-GENE-040426-719	DANRE04524
Sus scrofa	397654			PIGXX03541
Xenopus laevis	447155		Xenbase:XB-GENE-6078073
Xenopus tropicalis	448594		Xenbase:XB-GENE-953360
Pan troglodytes	454478	9598_0:00459a		PANTR14693
Canis lupus familiaris	479526			CANLF15595
Macaca mulatta	699083			MACMU13817

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements