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peptidylprolyl isomerase E

Summary

Gene Symbol

PPIE

Organism

Homo sapiens (human)

External Links

NCBI Gene

10450

PubChem

10450

Alliance of Genome Resources

HGNC:9258

Annotation

Keyword

3D-structure
Alternative splicing
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Rotamase
Spliceosome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UNP9	Cyclophilin E Cyclophilin-33 Rotamase E

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
protein peptidyl-prolyl isomerization	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

cellular process [inference]

protein folding

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of biological process [inference]

positive regulation of viral process [inference]

positive regulation of viral genome replication

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral genome replication

regulation of viral life cycle [inference]

regulation of viral genome replication [inference]

positive regulation of viral genome replication

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
secretory granule lumen	TAS
nuclear speck	IDA
U2-type catalytic step 2 spliceosome	IDA	28076346
intracellular membrane-bounded organelle	IBA
extracellular region	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

spliceosomal complex [inference]

U2-type spliceosomal complex [inference]

U2-type catalytic step 2 spliceosome

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

catalytic complex [inference]

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

ribonucleoprotein complex [inference]

spliceosomal complex [inference]

U2-type spliceosomal complex [inference]

U2-type catalytic step 2 spliceosome

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
peptidyl-prolyl cis-trans isomerase activity	IBA IDA TAS	11313484 18258190 20676357

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

cis-trans isomerase activity [inference]

peptidyl-prolyl cis-trans isomerase activity

catalytic activity, acting on a protein [inference]

peptidyl-prolyl cis-trans isomerase activity

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

cyclosporin A binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

single-stranded RNA binding [inference]

poly-purine tract binding [inference]

poly(A) binding

mRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptidyl-prolyl cis-trans isomerase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
isomerase activity

Displaying **all 3** entries
InterPro
Cyclophilin-like domain superfamily
Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site

Ortholog

Displaying entries **71 - 76** of 76 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Strigops habroptila	115616124			STRHB12534
Corvus moneduloides	116455117			CORMO11600
Scophthalmus maximus	118286186			SCOMX11402
Balaenoptera musculus	118898119			BALMU23914
Panthera leo	122227226			PANLE08724
Pongo pygmaeus	129039676	9600_0:0002d3

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 9, 2024