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translocase of outer mitochondrial membrane 40

Summary

Gene Symbol

TOMM40

Organism

Homo sapiens (human)

External Links

NCBI Gene

10452

PubChem

10452

Alliance of Genome Resources

HGNC:18001

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Mitochondrion outer membrane
Porin
Protein transport
Reference proteome
Transmembrane beta strand

Proteins

Displaying 1 entry
UniProt	Protein Name
O96008	Protein Haymaker Translocase of outer membrane 40 kDa subunit homolog p38.5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein import into mitochondrial matrix	IBA
protein insertion into mitochondrial outer membrane	NAS	18331822
monoatomic ion transport	IEA
ion transport	IEA
protein targeting to mitochondrion	IGI IMP ISS	15644312 31206022

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

transmembrane transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

mitochondrial transmembrane transport [inference]

protein import into mitochondrial matrix

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

outer mitochondrial membrane organization [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

membrane organization [inference]

mitochondrial membrane organization [inference]

outer mitochondrial membrane organization [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of localization [inference]

transport [inference]

monoatomic ion transport

mitochondrial transport [inference]

protein insertion into mitochondrial outer membrane

mitochondrial transmembrane transport [inference]

protein import into mitochondrial matrix

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

transmembrane transport [inference]

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

mitochondrial transmembrane transport [inference]

protein import into mitochondrial matrix

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

protein transport [inference]

intracellular protein transport [inference]

protein insertion into mitochondrial outer membrane

protein transmembrane transport [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to organelle [inference]

protein transmembrane import into intracellular organelle [inference]

protein import into mitochondrial matrix

establishment of protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

establishment of protein localization to mitochondrial membrane [inference]

protein insertion into mitochondrial outer membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
mitochondrial outer membrane translocase complex	IBA IDA	12198123 15644312
membrane	IDA	15644312
pore complex	IEA
mitochondrial inner membrane	IDA	24746669
mitochondrial outer membrane	ISS NAS TAS	10980201 18331822

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex

outer mitochondrial membrane protein complex [inference]

mitochondrial outer membrane translocase complex

TOM complex

mitochondrial protein-containing complex [inference]

outer mitochondrial membrane protein complex [inference]

mitochondrial outer membrane translocase complex

TOM complex

cellular anatomical entity [inference]

cytosol

membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

organelle membrane contact site [inference]

mitochondria-associated endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	27554484 31206022 31412244
protein transmembrane transporter activity	IBA ISS TAS	15644312
porin activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

passive transmembrane transporter activity [inference]

channel activity [inference]

wide pore channel activity [inference]

porin activity

macromolecule transmembrane transporter activity [inference]

protein transmembrane transporter activity

protein transporter activity [inference]

protein transmembrane transporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mitochondrial import receptor subunit

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
protein import into mitochondrial matrix

Displaying **all 3** entries
InterPro
Eukaryotic porin/Tom40
Porin domain superfamily
Tom40

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	35553	FB:FBgn0033074
Drosophila melanogaster	44978	FB:FBgn0016041
Mus musculus	53333	MGI:1858259	MOUSE53773
Caenorhabditis elegans	174431	WB:WBGene00007686
Rattus norvegicus	308416	RGD:1303022	RATNO16339
Danio rerio	322645	ZFIN:ZDB-GENE-030131-1365	DANRE11210
Xenopus laevis	379405	Xenbase:XB-GENE-17338826
Xenopus laevis	380301	Xenbase:XB-GENE-995156
Xenopus tropicalis	394730	Xenbase:XB-GENE-995150
Danio rerio	405895	ZFIN:ZDB-GENE-040426-2319	DANRE16317

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements