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cartilage associated protein

Summary

Gene Symbol

CRTAP

Organism

Homo sapiens (human)

External Links

NCBI Gene

10491

PubChem

10491

Alliance of Genome Resources

HGNC:2379

Annotation

Keyword

Disease variant
Dwarfism
Extracellular matrix
Glycoprotein
Hydroxylation
Osteogenesis imperfecta
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O75718

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein stabilization	IMP	19846465
chaperone-mediated protein folding	ISS
collagen fibril organization	IBA
negative regulation of post-translational protein modification	IMP	19846465
spermatogenesis	IEA

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

chaperone-mediated protein folding

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein-containing complex	ISS
endoplasmic reticulum lumen	TAS
endoplasmic reticulum	IBA IDA	19846465 20089953
extracellular space	IDA	19846465

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

extracellular space

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI ISS	30021884 33961781
collagen binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

collagen binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cartilage associated protein

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
collagen binding
collagen fibril organization

Displaying 1 entry
InterPro
Tetratricopeptide-like helical domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110337	osteogenesis imperfecta type 7	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	56693		MGI:1891221	MOUSE63809
Caenorhabditis elegans	178435		WB:WBGene00013531
Rattus norvegicus	363158		RGD:1565180	RATNO41417
Danio rerio	406626		ZFIN:ZDB-GENE-040426-2619	DANRE15713
Pan troglodytes	460255	9598_0:00113b
Canis lupus familiaris	485577			CANLF08924
Bos taurus	540924			BOVIN17209
Xenopus tropicalis	549401		Xenbase:XB-GENE-1009954
Macaca mulatta	705949			MACMU29195
Bos taurus	781218			BOVIN17209