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unc-13 homolog B

Summary

Gene Symbol

UNC13B

Organism

Homo sapiens (human)

External Links

NCBI Gene

10497

PubChem

10497

Alliance of Genome Resources

HGNC:12566

Annotation

Keyword

Alternative splicing
Calcium
Cell membrane
Coiled coil
Cytoplasm
Exocytosis
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Synapse
Zinc
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q4LE73
O14795	Munc13-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
neuronal dense core vesicle exocytosis	ISS
positive regulation of protein secretion	IDA	19641095
positive regulation of inhibitory postsynaptic potential	ISS
presynaptic dense core vesicle exocytosis	IBA
synaptic vesicle priming	IBA ISS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

acrosomal vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

presynaptic dense core vesicle exocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

membrane docking [inference]

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis [inference]

synaptic vesicle docking

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

exocytic process [inference]

vesicle docking involved in exocytosis [inference]

synaptic vesicle docking

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

acrosomal vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

presynaptic dense core vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

reproductive process [inference]

acrosomal vesicle exocytosis

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

intracellular chemical homeostasis [inference]

intracellular glucose homeostasis [inference]

cellular response to glucose stimulus

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose [inference]

cellular response to glucose stimulus

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to glucose stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

acrosomal vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

presynaptic dense core vesicle exocytosis

vesicle-mediated transport in synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

acrosomal vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

presynaptic dense core vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

calcium-ion regulated exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

acrosomal vesicle exocytosis

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

presynaptic dense core vesicle exocytosis

signal release [inference]

signal release from synapse [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

establishment of localization in cell [inference]

synaptic vesicle exocytosis [inference]

calcium ion-regulated exocytosis of neurotransmitter [inference]

presynaptic dense core vesicle exocytosis

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

presynaptic dense core vesicle exocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

presynaptic dense core vesicle exocytosis

organelle localization [inference]

vesicle localization [inference]

secretory granule localization [inference]

dense core granule localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

presynaptic dense core vesicle exocytosis

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

presynaptic dense core vesicle exocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

dense core granule exocytosis [inference]

neuronal dense core vesicle exocytosis

presynaptic dense core vesicle exocytosis

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis [inference]

synaptic vesicle docking

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of synaptic vesicle priming

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of synaptic vesicle priming

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of inhibitory postsynaptic potential

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming [inference]

positive regulation of synaptic vesicle priming

positive regulation of protein-containing complex assembly [inference]

positive regulation of synaptic vesicle priming

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of synaptic vesicle priming

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of synaptic vesicle priming

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of synaptic vesicle priming

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

regulation of synaptic vesicle priming [inference]

positive regulation of synaptic vesicle priming

positive regulation of protein-containing complex assembly [inference]

positive regulation of synaptic vesicle priming

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of synaptic vesicle priming

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of inhibitory postsynaptic potential

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of inhibitory postsynaptic potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
synaptic vesicle membrane	IBA
presynaptic active zone cytoplasmic component	IBA
membrane	IDA	9607201
Golgi apparatus	IDA	10233166 16138900
terminal bouton	IBA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

cytoplasmic region [inference]

cell cortex region [inference]

presynaptic active zone cytoplasmic component

cytosol

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

neuromuscular junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

presynaptic active zone

presynapse [inference]

terminal bouton

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16138900 33961781
diacylglycerol binding	NAS	10233166 16138900
calmodulin binding	IBA ISS
small GTPase binding	NAS	19641095
syntaxin-1 binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

SNARE binding [inference]

syntaxin binding [inference]

syntaxin-1 binding

calmodulin binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

GTP-dependent protein binding

lipid binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protein UNC-13 a

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 14 in total

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Gene Ontology
calcium ion binding
calmodulin binding
chemical synaptic transmission
dense core granule priming
diacylglycerol binding
metal ion binding
neuromuscular junction development
phospholipid binding
presynaptic dense core vesicle exocytosis
synaptic transmission, glutamatergic

Displaying **all 7** entries
InterPro
C2 domain superfamily
C2 domain
MUN domain
Mammalian uncoordinated homology 13, domain 2
Munc13 homology 1
Protein Unc-13
Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	22249		MGI:1342278	MOUSE42823
Drosophila melanogaster	43841		FB:FBgn0025726
Rattus norvegicus	64830		RGD:619723
Caenorhabditis elegans	172497		WB:WBGene00006752
Pan troglodytes	464150	9598_0:0029df		PANTR43903
Macaca mulatta	697393			MACMU13390
Pongo abelii	100172629	9601_0:002818
Ciona intestinalis	100176945			CIOIN05888
Taeniopygia guttata	100224334			TAEGU30616
Danio rerio	100329499		ZFIN:ZDB-GENE-120502-2

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements