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Guidelines

MIRAGE

pitrilysin metallopeptidase 1

Summary

Gene Symbol

PITRM1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10531

PubChem

10531

Alliance of Genome Resources

HGNC:17663

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Disease variant
Disulfide bond
Metal-binding
Metalloprotease
Mitochondrion
Neurodegeneration
Proteomics identification
Reference proteome
Transit peptide
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q5JRX3	Pitrilysin metalloproteinase 1
A0A7I2V397	Pitrilysin metalloproteinase 1
A0A0A0MRX9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteolysis	IDA	10360838 19196155
proteolysis	IMP	16849325 24931469
protein targeting to mitochondrion	TAS
protein processing	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to mitochondrion

establishment of protein localization to organelle [inference]

establishment of protein localization to mitochondrion [inference]

protein targeting to mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrion	IDA
mitochondrion	HTP	34800366
mitochondrial matrix	TAS
mitochondrial matrix	IDA	16849325 19196155
mitochondrial matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	IDA	10360838 19196155
metalloendopeptidase activity	IMP	16849325 24931469
metalloendopeptidase activity	IBA
protein binding	IPI	24931469
enzyme activator activity	TAS	9733512

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

presequence protease

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
metal ion binding
metalloendopeptidase activity
proteolysis

Displaying **all 4** entries
InterPro
Metalloenzyme, LuxS/M16 peptidase-like
Peptidase M16, C-terminal
Peptidase M16, N-terminal
Peptidase M16C associated

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070411	autosomal recessive spinocerebellar ataxia 30	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10531	Xenbase:XB-GENE-952658
Mus musculus	69617	Xenbase:XB-GENE-952658	MOUSE11329
Rattus norvegicus	307081		RATNO12740
Danio rerio	406808		DANRE29031
Pan troglodytes	450267		PANTR00033
Canis lupus familiaris	478018		CANLF06599
Bos taurus	513230		BOVIN04665
Macaca mulatta	710684		MACMU44915
Equus caballus	100070807		HORSE26442
Pongo abelii	100189669		PONAB01431

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Last updated: December 8, 2025