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phospholipase A2 group VI

Summary

Gene Symbol

PLA2G6

Organism

Macaca nemestrina (pig-tailed macaque)

External Links

NCBI Gene: 105464455
KEGG Gene ID: mni:105464455
PubChem: 105464455

Annotation

Keyword

ANK repeat
Hydrolase
Lipid degradation
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A2K6CNL2
A0A2K6CNN4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cardiolipin acyl-chain remodeling	IEA	30032202
positive regulation of ceramide biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular component biogenesis [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium-independent phospholipase A2 activity	IEA	30032202
protein binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase A2 activity [inference]

calcium-independent phospholipase A2 activity

carboxylic ester hydrolase activity [inference]

phospholipase A2 activity [inference]

calcium-independent phospholipase A2 activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K16343

Name

calcium-independent phospholipase A2 [EC:3.1.1.4]

References

Rhea

H₂O + a 1,2-diacyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + a 1-acyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + 1-O-alkyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

9442064

Ortholog

Displaying entries **41 - 50** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Cavia porcellus	100726758		CAVPO13094
Melopsittacus undulatus	101872358		MELUD06066
Monodelphis domestica	100016178		MONDO00647
Pelodiscus sinensis	102443808		PELSI07349
Vombatus ursinus	114049954		VOMUR16971
Bos indicus x Bos taurus	113892234		BOBOX41373
Otolemur garnettii	100949513		OTOGA17411
Takifugu rubripes	101073182		TAKRU16592
Chinchilla lanigera	102015394		CHILA04521
Aotus nancymaae	105721747		AOTNA31787

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024