GlyCosmos Portal

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein tyrosine phosphatase activity	IEA	22301074 30032202
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA	22301074
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA	22301074 30032202
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

inositol phosphate phosphatase activity [inference]

inositol tetrakisphosphate phosphatase activity [inference]

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4-bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

phosphatidylinositol trisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Cercopithecoidea

Group Name

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

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Gene Ontology
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
lipid metabolic process
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cell cycle G1/S phase transition
negative regulation of cell migration
negative regulation of cell population proliferation
negative regulation of epithelial to mesenchymal transition
negative regulation of focal adhesion assembly
negative regulation of keratinocyte migration
negative regulation of peptidyl-serine phosphorylation

Displaying **all 10** entries
InterPro
Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
C2 domain superfamily
PTEN, phosphatase domain
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase, catalytic
Protein-tyrosine phosphatase-like
Tensin phosphatase, C2 domain
Tensin-type phosphatase domain
Tyrosine-specific protein phosphatase, PTPase domain
Tyrosine-specific protein phosphatases domain

KEGG BRITE Database

Orthology

K01110

Name

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]

References

Rhea

RHEA:20629

H₂O

phosphate

Enzyme

3.1.3.16

PMID

RHEA:47004

H₂O

phosphate

Enzyme

3.1.3.16

PMID

RHEA:10684

H₂O

phosphate

Enzyme

3.1.3.48

PMID

RHEA:25017

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

Enzyme

3.1.3.67

PMID

Ortholog

Displaying entries **21 - 30** of 77 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Oryzias latipes	101171856		ORYLA04962
Anas platyrhynchos platyrhynchos	101798136		ANAPP22764
Ficedula albicollis	101815785		FICAL08886
Macaca fascicularis	101867036	9541_0:0026c3	MACFA42935
Chrysemys picta bellii	101934509		CHRPI13897
Capra hircus	102185891		CAPHI18021
Latimeria chalumnae	102348548		LATCH03568
Vicugna pacos	102530539		VICPA03555
Astyanax mexicanus	103025186		ASTMX07666
Astyanax mexicanus	103046962		ASTMX03215