GlyCosmos Portal

Submissions

phosphatase and tensin homolog

Summary

Gene Symbol

PTEN

Organism

Macaca nemestrina (pig-tailed macaque)

External Links

NCBI Gene: 105480917
KEGG Gene ID: mni:105480917
PubChem: 105480917

Annotation

Keyword

Apoptosis
Cell projection
Cytoplasm
Lipid metabolism
Neurogenesis
Nucleus
Protein phosphatase
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A2K6B6A9	Phosphatase and tensin homolog
A0A2K6B6B3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA	30032202
phosphatidylinositol dephosphorylation	IEA	22301074 30032202
negative regulation of cell population proliferation	IEA	22301074 30032202
protein dephosphorylation	IEA	22301074 30032202
cell motility	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

protein dephosphorylation

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

protein dephosphorylation

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cell motility

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA	30032202
cell projection	IEA	30032202
nucleus	IEA	30032202
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

cell projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein tyrosine phosphatase activity	IEA	22301074 30032202
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA	22301074
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA	22301074 30032202
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

inositol phosphate phosphatase activity [inference]

inositol tetrakisphosphate phosphatase activity [inference]

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4-bisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

phosphatidylinositol trisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Cercopithecoidea

Group Name

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying entries **11 - 20** of 36 in total

« First

‹ Prev

1

2

3

4

Next ›

Last »
Gene Ontology
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
lipid metabolic process
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cell cycle G1/S phase transition
negative regulation of cell migration
negative regulation of cell population proliferation
negative regulation of epithelial to mesenchymal transition
negative regulation of focal adhesion assembly
negative regulation of keratinocyte migration
negative regulation of peptidyl-serine phosphorylation

Displaying **all 10** entries
InterPro
Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
C2 domain superfamily
PTEN, phosphatase domain
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase, catalytic
Protein-tyrosine phosphatase-like
Tensin phosphatase, C2 domain
Tensin-type phosphatase domain
Tyrosine-specific protein phosphatase, PTPase domain
Tyrosine-specific protein phosphatases domain

KEGG BRITE Database

Orthology

K01110

Name

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]

References

Rhea

RHEA:20629

H₂O

phosphate

Enzyme

3.1.3.16

PMID

RHEA:47004

H₂O

phosphate

Enzyme

3.1.3.16

PMID

RHEA:10684

H₂O

phosphate

Enzyme

3.1.3.48

PMID

RHEA:25017

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

Enzyme

3.1.3.67

PMID

Ortholog

Displaying entries **51 - 60** of 77 in total

« First

‹ Prev

1

2

3

4

5

6

7

8

Next ›

Last »
Species	Gene ID	OrthoDB	Orthologous MAtrix
Cyprinus carpio carpio	109101447		CYPCA106237
Cyprinus carpio carpio	109108026		CYPCA87953
Cyprinus carpio carpio	109108030		CYPCA100830
Crocodylus porosus	109312531		CROPO21604
Phascolarctos cinereus	110199935		PHACI19695
Piliocolobus tephrosceles	111551321	591936_0:0023c7
Theropithecus gelada	112631315	9565_0:00247a
Vulpes vulpes	112931976		VULVU27621
Pseudonaja textilis	113449026		PSETE22795
Athene cunicularia	113481870		ATHCN18503