1-acylglycerol-3-phosphate O-acyltransferase 2

Summary
Gene Symbol
  • AGPAT2
Aliases
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
  • LPAAT-beta
  • LPLAT2
  • lysophosphatidic acid acyltransferase-beta
  • lysophospholipid acyltransferase 2
Organism
Homo sapiens (human)
External Links
NCBI Gene
10555
HGNC
325
KEGG Gene ID
hsa:10555
PubChem
10555
Alliance of Genome Resources
Annotation
Keyword
  • Acyltransferase
  • Alternative splicing
  • Congenital generalized lipodystrophy
  • Diabetes mellitus
  • Disease variant
  • Endoplasmic reticulum
  • Phospholipid biosynthesis
  • Reference proteome
  • Signal
  • Transmembrane helix
Proteins
Displaying all 2 entries
UniProt Protein Name
A0A024R8F9
O15120
  • 1-acylglycerol-3-phosphate O-acyltransferase 2
  • Lysophosphatidic acid acyltransferase beta
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000169692

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K13509
Name
lysophosphatidate acyltransferase [EC:2.3.1.51]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 80 in total
DO ID Disease Name Source
DOID:0050440 familial partial lipodystrophy
DOID:0050585 congenital generalized lipodystrophy
DOID:0050700 cardiomyopathy
DOID:0050782 Zollinger-Ellison syndrome
DOID:0060224 atrial fibrillation
DOID:0060249 scoliosis
DOID:0060318 acute promyelocytic leukemia
DOID:0060321 umbilical hernia
DOID:0060327 omphalocele
DOID:0060334 transient neonatal diabetes mellitus
The Human Phenotype Ontology
Displaying entries 1 - 10 of 60 in total
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0000065 Labial hypertrophy
HP:0000098 Tall stature
HP:0000141 Amenorrhea
HP:0000147 Polycystic ovaries
HP:0000158 Macroglossia
HP:0000294 Low anterior hairline
HP:0000303 Mandibular prognathia
HP:0000325 Triangular face
HP:0000336 Prominent supraorbital ridges
Displaying all 2 entries
Disease ID Disease Name
ORPHA:528
  • Berardinelli-Seip congenital lipodystrophy
OMIM:608594
  • congenital generalized lipodystrophy type 1
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP000277
Gene Name
1-acylglycerol-3-phosphate O-acyltransferase 2

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024