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solute carrier family 35 member A1

Summary

Gene Symbol

SLC35A1

Aliases

CMP-Sia-Tr
CMP-sialic acid transporter
CMPST
hCST

Organism

Homo sapiens (human)

External Links

NCBI Gene

10559

GGDB ID

gg178

HGNC

11021

mRNA

NM_006416

map

6q15

Protein

NP_006407

OMIM

605634

KEGG Gene ID

hsa:10559

PubChem

10559

Alliance of Genome Resources

HGNC:11021

Annotation

Keyword

Alternative splicing
Antiport
Congenital disorder of glycosylation
Disease variant
Golgi apparatus
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P78382	Solute carrier family 35 member A1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	TAS	9644260
N-acetylneuraminate metabolic process	IEA
CMP-N-acetylneuraminate biosynthetic process	IEA
CMP-N-acetylneuraminate transmembrane transport	ISS
CMP-N-acetylneuraminate transmembrane transport	IDA	15576474

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

amide metabolic process [inference]

N-acetylneuraminate metabolic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process

protein metabolic process [inference]

protein modification process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

phosphorus metabolic process [inference]

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

protein metabolic process [inference]

protein modification process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process

macromolecule modification [inference]

protein modification process

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

N-acetylneuraminate metabolic process

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organonitrogen compound metabolic process [inference]

N-acetylneuraminate metabolic process

protein metabolic process [inference]

protein modification process

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

N-acetylneuraminate metabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

phosphorus metabolic process [inference]

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

CMP-N-acetylneuraminate metabolic process [inference]

CMP-N-acetylneuraminate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

CMP-N-acetylneuraminate biosynthetic process

transmembrane transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport [inference]

CMP-N-acetylneuraminate transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport [inference]

CMP-N-acetylneuraminate transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

CMP-N-acetylneuraminate transmembrane transport

nucleobase-containing compound transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport [inference]

CMP-N-acetylneuraminate transmembrane transport

carbohydrate derivative transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport [inference]

CMP-N-acetylneuraminate transmembrane transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide-sugar transmembrane transport [inference]

pyrimidine nucleotide-sugar transmembrane transport [inference]

CMP-N-acetylneuraminate transmembrane transport

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Golgi membrane	TAS
Golgi membrane	IBA
Golgi apparatus	TAS	9644260
plasma membrane	TAS	9644260
membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
CMP-N-acetylneuraminate transmembrane transporter activity	ISS
CMP-N-acetylneuraminate transmembrane transporter activity	TAS
CMP-N-acetylneuraminate transmembrane transporter activity	IBA
protein binding	IPI	32296183
antiporter activity	ISS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

CMP-N-acetylneuraminate transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

pyrimidine nucleotide-sugar transmembrane transporter activity [inference]

CMP-N-acetylneuraminate transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

nucleotide-sugar transmembrane transporter activity [inference]

pyrimidine nucleotide-sugar transmembrane transporter activity [inference]

CMP-N-acetylneuraminate transmembrane transporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
UDP-galactose transmembrane transporter activity
pyrimidine nucleotide-sugar transmembrane transporter activity

Displaying 1 entry
InterPro
Nucleotide-sugar transporter

GlycoGene Database (GGDB)

GGDB ID

gg178

Gene Symbol

SLC35A1

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_232884	XM_232884
Mus musculus	NP_036025	NM_011895

KEGG BRITE Database

Orthology

K15272

Name

solute carrier family 35 (UDP-sugar transporter), member A1/2/3

References

12759756

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070258	congenital disorder of glycosylation type IIf	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 35 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000093	Proteinuria
HP:0000252	Microcephaly
HP:0000322	Short philtrum
HP:0000465	Webbed neck
HP:0000490	Deeply set eye
HP:0000601	Hypotelorism
HP:0000639	Nystagmus
HP:0001249	Intellectual disability
HP:0001250	Seizure

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:603585	SLC35A1-congenital disorder of glycosylation
ORPHA:238459	SLC35A1-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

SLC35A1-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIf; CDG2F

KEGG Diseases

Congenital disorders of glycosylation type II

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10559	Xenbase:XB-GENE-1001033
Mus musculus	24060		MOUSE42515
Xenopus tropicalis	31255	Xenbase:XB-GENE-1001033
Rattus norvegicus	313139		RATNO32850
Canis lupus familiaris	403594		CANLF02970
Pan troglodytes	462874		PANTR38669
Bos taurus	536838		BOVIN35718
Macaca mulatta	699113		MACMU34359
Takifugu rubripes	777968		TAKRU14075
Danio rerio	100004536		DANRE18603

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements