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sperm associated antigen 5

Summary

Gene Symbol

SPAG5

Organism

Homo sapiens (human)

External Links

NCBI Gene

10615

PubChem

10615

Alliance of Genome Resources

HGNC:13452

Annotation

Keyword

Centromere
Chromosome
Coiled coil
Cytoskeleton
Kinetochore
Microtubule
Mitosis
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96R06	Astrin Deepest Mitotic spindle-associated protein p126

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
mitotic sister chromatid segregation	IMP	21402792
spindle organization	IMP	21402792
chromosome segregation	IMP	21402792
positive regulation of intracellular transport	IMP	27462074
establishment of spindle orientation	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization

establishment of spindle localization [inference]

establishment of spindle orientation

cell cycle process [inference]

spindle organization

chromosome segregation

nuclear chromosome segregation [inference]

sister chromatid segregation [inference]

mitotic sister chromatid segregation

spindle localization [inference]

establishment of spindle localization [inference]

establishment of spindle orientation

mitotic cell cycle process [inference]

mitotic sister chromatid segregation

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule organizing center [inference]

protein localization to centrosome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization

establishment of spindle localization [inference]

establishment of spindle orientation

chromosome organization [inference]

sister chromatid segregation [inference]

mitotic sister chromatid segregation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule organizing center [inference]

protein localization to centrosome

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of spindle localization [inference]

establishment of spindle orientation

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of spindle orientation

organelle localization [inference]

spindle localization [inference]

establishment of spindle localization [inference]

establishment of spindle orientation

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of spindle orientation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule organizing center [inference]

protein localization to centrosome

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport

positive regulation of transport [inference]

positive regulation of intracellular transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport

regulation of metaphase plate congression

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of spindle assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of transport [inference]

positive regulation of intracellular transport

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of spindle assembly [inference]

positive regulation of spindle assembly

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

regulation of organelle assembly [inference]

regulation of spindle assembly [inference]

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of cellular process [inference]

positive regulation of intracellular transport

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of spindle assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

regulation of cytoskeleton organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of spindle assembly

regulation of microtubule cytoskeleton organization [inference]

regulation of spindle organization [inference]

regulation of spindle assembly [inference]

positive regulation of spindle assembly

regulation of organelle assembly [inference]

regulation of spindle assembly [inference]

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of attachment of spindle microtubules to kinetochore

positive regulation of cell cycle process [inference]

positive regulation of spindle assembly

regulation of spindle organization [inference]

regulation of spindle assembly [inference]

positive regulation of spindle assembly

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of spindle assembly

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
kinetochore	IDA	21402792 27462074
cytoplasm	IDA	27462074
cytosol	IDA
nuclear body	IDA
midbody	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

spindle pole [inference]

mitotic spindle pole

cytoplasm

microtubule organizing center [inference]

ciliary basal body

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

spindle [inference]

mitotic spindle

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

spindle [inference]

mitotic spindle

supramolecular complex [inference]

kinetochore

microtubule end [inference]

microtubule plus-end

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18361916 19197158 20852589 21402792 22965910 23953116 24424245 25416956 26297806 26871637 27462074 31413325 31515488 32296183 33961781 36217029
microtubule binding	IDA	27462074

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sperm-associated antigen 5

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cell division
regulation of attachment of spindle microtubules to kinetochore

Displaying 1 entry
InterPro
Sperm-associated antigen 5

Ortholog

Displaying entries **51 - 56** of 56 in total

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Species	Gene ID	Orthologous MAtrix
Rhinopithecus bieti	108539925	RHIBE32303
Phascolarctos cinereus	110192284	PHACI23289
Bos indicus x Bos taurus	113878182	BOBOX15544
Rhinolophus ferrumequinum	117013628	RHIFE07692
Balaenoptera musculus	118887149	BALMU11147
Panthera leo	122206103	PANLE04297