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periostin

Summary

Gene Symbol

POSTN

Organism

Homo sapiens (human)

External Links

NCBI Gene

10631

PubChem

10631

Alliance of Genome Resources

HGNC:16953

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Disulfide bond
Extracellular matrix
Gamma-carboxyglutamic acid
Glycoprotein
Golgi apparatus
Heparin-binding
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15063	Osteoblast-specific factor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
cellular response to fibroblast growth factor stimulus	IEA
bone regeneration	IEA
neuron projection extension	IEA
cellular response to vitamin K	IDA	18450759
response to hypoxia	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

cell adhesion

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to vitamin K

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

developmental process [inference]

anatomical structure development [inference]

tissue development

regeneration [inference]

tissue regeneration [inference]

bone regeneration

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth [inference]

tissue regeneration [inference]

bone regeneration

developmental cell growth [inference]

neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to external stimulus [inference]

response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

response to vitamin [inference]

response to vitamin K [inference]

cellular response to vitamin K

cellular response to vitamin [inference]

cellular response to vitamin K

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

response to abiotic stimulus [inference]

response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

response to transforming growth factor beta [inference]

cellular response to transforming growth factor beta stimulus

response to fibroblast growth factor [inference]

cellular response to fibroblast growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

response to activity [inference]

response to muscle activity

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

response to vitamin [inference]

response to vitamin K [inference]

cellular response to vitamin K

cellular response to vitamin [inference]

cellular response to vitamin K

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to estradiol

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

response to ketone [inference]

response to vitamin K [inference]

cellular response to vitamin K

cellular response to ketone [inference]

cellular response to vitamin K

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to vitamin K

response to oxygen-containing compound [inference]

response to estradiol

response to ketone [inference]

response to vitamin K [inference]

cellular response to vitamin K

cellular response to ketone [inference]

cellular response to vitamin K

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to vitamin K

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin K

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to vitamin K

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of chemokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of chemokine (C-X-C motif) ligand 2 production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of chemokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of chemokine (C-X-C motif) ligand 2 production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of chemokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of chemokine (C-X-C motif) ligand 2 production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

negative regulation of cell-matrix adhesion

negative regulation of cell-substrate adhesion [inference]

regulation of substrate adhesion-dependent cell spreading [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of chemokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of chemokine (C-X-C motif) ligand 2 production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of smooth muscle cell migration

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of chemokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of chemokine (C-X-C motif) ligand 2 production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production [inference]

positive regulation of chemokine (C-X-C motif) ligand 2 production

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular matrix	IBA ISS
collagen-containing extracellular matrix	HDA IDA	18450759 20551380 25037231 27068509 27559042 28327460 28675934
neuromuscular junction	IEA
trans-Golgi network	IDA	19478074
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

cell junction [inference]

synapse [inference]

neuromuscular junction

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19478074
heparin binding	ISS
extracellular matrix structural constituent	RCA	20551380 25037231 27068509 27559042 28327460 28675934
metal ion binding	IDA	18450759
cell adhesion molecule binding	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

cell adhesion molecule binding

ion binding [inference]

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Fasciclin-1

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
cell adhesion molecule binding
extracellular matrix organization

Displaying **all 2** entries
InterPro
FAS1 domain superfamily
FAS1 domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0080010	bone structure disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1474	aggressive periodontitis	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources
DOID:824	periodontitis	Alliance of Genome Resources
DOID:90	degenerative disc disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	41455		FB:FBgn0260745
Mus musculus	50706		MGI:1926321	MOUSE37736
Caenorhabditis elegans	172829		WB:WBGene00009162
Bos taurus	281960			BOVIN03763
Danio rerio	337176		ZFIN:ZDB-GENE-030131-9120	DANRE08674
Rattus norvegicus	361945		RGD:1305285	RATNO23158
Danio rerio	378983		ZFIN:ZDB-GENE-091113-23
Pan troglodytes	452543	9598_0:003928		PANTR07624
Canis lupus familiaris	477298			CANLF09797
Macaca mulatta	695528			MACMU16924

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements