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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

Summary

Gene Symbol

B3GNT2

Aliases

B3GN-T1
B3GN-T2
B3GNT-2
BETA3GNT

Organism

Homo sapiens (human)

External Links

NCBI Gene

10678

GGDB ID

gg116

HGNC

15629

mRNA

NM_006577

map

2p15

Protein

NP_006568

OMIM

605581

KEGG Gene ID

hsa:10678

PubChem

10678

Alliance of Genome Resources

HGNC:15629

Annotation

Keyword

3D-structure
Alternative splicing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NY97	Beta-1,3-N-acetylglucosaminyltransferase 1 Beta-1,3-galactosyltransferase 7 Beta-3-Gx-T7 UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
O-glycan processing	TAS
axon guidance	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of smell

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18826941 33961781
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	IBA IDA TAS	11042166 25279697 9892646
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity

UDP-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

beta-1,3-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Galactosyltransferase

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hexosyltransferase activity
transferase activity

Displaying 1 entry
InterPro
Glycosyl transferase, family 31

Human Protein Atlas

ENSG00000170340

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg116

Gene Symbol

B3GNT2

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G00055MO	R	G29487JS	R	11042166

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G00055MO	R	G29487JS	R	11042166
UDP-GlcNAc	G58896AZ	2AB	G70874WW	2AB	11283017
UDP-GlcNAc	G32723SL	O-glycan Synthesis	G23438NR	O-glycan Synthesis
UDP-GlcNAc	G64973KT	O-glycan Synthesis	G97494HI	O-glycan Synthesis
UDP-GlcNAc	G18938DW	PA	G79431NA	PA	15620693

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-Gal	G57321FI	[alpha]1-OBn	9892646
UDP-Gal	G68544GH	[alpha]1-OBn	9892646
UDP-Gal	G49108TO	[beta]1-OBn	9892646
UDP-Gal	G61418DU	[beta]1-OBn	9892646
UDP-GalNAc	G09546QO	[alpha]1-OpNP	9892646

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_223674	XM_223674
Mus musculus	NP_058584	NM_016888

KEGG BRITE Database

Orthology

K00741

Name

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.149]

References

11042166

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05974	2.4.1.149	G84034JH	G91404LJ
R05975	2.4.1.149	G58896AZ	G70874WW

Rhea

RHEA:14389

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + UDP-N-acetyl-α-D-glucosamine

an N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.149

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001370
Gene Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

Ortholog

Displaying entries **81 - 89** of 89 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Strigops habroptila	115609944		STRHB17521
Corvus moneduloides	116441505		CORMO17879
Chelonoidis abingdonii	116815172		CHEAB11878
Rhinolophus ferrumequinum	117033196		RHIFE24505
Balaenoptera musculus	118905850		BALMU05114
Panthera leo	122216101		PANLE01207
Ursus americanus	123785971		URSAM31900
Pongo pygmaeus	129030457	9600_0:000a25
Ovis aries	132657135		SHEEP13713

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements