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cofilin 1

Summary

Gene Symbol

CFL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1072

PubChem

1072

Alliance of Genome Resources

HGNC:1874

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Cell membrane
Cell projection
Cytoskeleton
Direct protein sequencing
Host-virus interaction
Isopeptide bond
Membrane
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
V9HWI5	Cofilin, non-muscle isoform
P23528	18 kDa phosphoprotein Cofilin, non-muscle isoform

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
positive regulation of embryonic development	ISS
mitotic cytokinesis	IBA
actin cytoskeleton organization	TAS	10436159
establishment of spindle localization	ISS
Rho protein signal transduction	TAS	10436159

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

establishment of spindle localization

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

spindle localization [inference]

establishment of spindle localization

mitotic cell cycle process [inference]

mitotic cytokinesis

actin filament-based process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

microtubule cytoskeleton organization [inference]

establishment of spindle localization

actin cytoskeleton organization

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

actin filament depolymerization

actin filament fragmentation

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

actin filament depolymerization

actin filament fragmentation

supramolecular fiber organization [inference]

actin filament organization [inference]

actin polymerization or depolymerization [inference]

actin filament depolymerization

actin filament fragmentation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

positive regulation by host of viral process

response to other organism [inference]

response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

localization [inference]

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of spindle localization

establishment of organelle localization [inference]

establishment of spindle localization

organelle localization [inference]

spindle localization [inference]

establishment of spindle localization

establishment of organelle localization [inference]

establishment of spindle localization

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of embryonic development

positive regulation of multicellular organismal process [inference]

positive regulation of embryonic development

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

positive regulation of developmental process [inference]

positive regulation of embryonic development

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

positive regulation of embryonic development

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendritic spine morphogenesis

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of embryonic development

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

positive regulation of embryonic development

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GO Term	Evidence Code	PMID
membrane	HDA	19946888
focal adhesion	HDA IDA	21423176 29162887
ruffle membrane	IEA
nuclear matrix	IEA
lamellipodium membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane region [inference]

cell projection membrane [inference]

nuclear matrix

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

site of polarized growth [inference]

growth cone

leading edge membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12361576 15161933 15846844 16189514 16713569 17853892 19424295 20029029 20133759 21516116 21525957 24658140 25416956 25556234 29892012 30021884 31515488 31980649 32296183 32814053 33961781 35271311
actin filament binding	IBA IDA ISS	11812157

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

actin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
actin binding
actin filament binding
actin filament depolymerization
actin filament fragmentation
actin filament severing

Displaying **all 3** entries
InterPro
ADF-H/Gelsolin-like domain superfamily
ADF/Cofilin
Actin-depolymerising factor homology domain

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050562	West syndrome	Alliance of Genome Resources
DOID:0050731	vitamin B12 deficiency	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0110934	nemaline myopathy 7	Alliance of Genome Resources
DOID:11457	brain compression	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:1875	impotence	Alliance of Genome Resources
DOID:4948	gallbladder carcinoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12631	MGI:101757	MOUSE25051
Rattus norvegicus	29271	RGD:69285	RATNO17998
Drosophila melanogaster	37841	FB:FBgn0011726
Caenorhabditis elegans	178640	WB:WBGene00006794
Danio rerio	321496	ZFIN:ZDB-GENE-030131-215
Xenopus laevis	379172	Xenbase:XB-GENE-6251620
Xenopus laevis	379258	Xenbase:XB-GENE-1016488
Xenopus tropicalis	407855	Xenbase:XB-GENE-1016481
Sus scrofa	445532		PIGXX16785
Canis lupus familiaris	476022		CANLF06044

GlyTouCan

GlyComb

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements