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O-GlcNAcase

Summary

Gene Symbol

Aliases

MEA5
NCOAT
nuclear cytoplasmic O-GlcNAcase and acetyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

10724

HGNC

7056

PubChem

10724

Alliance of Genome Resources

HGNC:7056

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Glycosidase
Host-virus interaction
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O60502	Beta-N-acetylglucosaminidase Beta-N-acetylhexosaminidase Beta-hexosaminidase Meningioma-expressed antigen 5 N-acetyl-beta-D-glucosaminidase N-acetyl-beta-glucosaminidase Nuclear cytoplasmic O-GlcNAcase and acetyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein deglycosylation	IDA	11148210
protein O-linked glycosylation	NAS	26363795
N-acetylglucosamine metabolic process	IDA	11148210
glycoprotein catabolic process	TAS	9811929
glycoprotein metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

protein catabolic process [inference]

glycoprotein catabolic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein deglycosylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

protein catabolic process [inference]

glycoprotein catabolic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein deglycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

protein metabolic process [inference]

glycoprotein metabolic process

protein catabolic process [inference]

glycoprotein catabolic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein deglycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein deglycosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

glucosamine-containing compound metabolic process [inference]

N-acetylglucosamine metabolic process

glycoprotein metabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process

protein catabolic process [inference]

glycoprotein catabolic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein deglycosylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IEA
cytosol	IDA	11148210
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity	IDA IEA	11148210

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hexosaminidase activity [inference]

hyalurononglucosaminidase activity

beta-N-acetylhexosaminidase activity [inference]

beta-N-acetylglucosaminidase activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000198408

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:48876

H₂O

N-acetyl-D-glucosamine

Enzyme

3.2.1.169

PMID

RHEA:48892

H₂O

N-acetyl-D-glucosamine

Enzyme

3.2.1.169

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **205** in total

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DO ID	Disease Name	Source
DOID:13507	trigonitis	DisGeNET
DOID:2723	dermatitis	DisGeNET
DOID:0050570	congenital disorder of glycosylation type I	DisGeNET
DOID:0050635	alternating hemiplegia of childhood	DisGeNET
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0060123	connective tissue benign neoplasm	DisGeNET
DOID:0060173	Timothy syndrome	DisGeNET
DOID:0060180	colitis	DisGeNET
DOID:0060189	ileitis	DisGeNET
DOID:0060190	ileocolitis	DisGeNET

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	181164	WB:WBGene00020596
Drosophila melanogaster	42518	FB:FBgn0038870
Danio rerio	324487	ZFIN:ZDB-GENE-030131-3208	DANRE05037
Astyanax mexicanus	103032082		ASTMX18102
Ictalurus punctatus	108263439		ICTPU27127
Electrophorus electricus	113585838		ELEEL36093
Salmo salar	106604352		SALSA64469
Salmo trutta	115152980		SALTR07124
Salmo trutta	115194036		SALTR91160
Oryzias latipes	101166655		ORYLA05065

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Acknowledgements