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kinesin family member 1C

Summary

Gene Symbol

KIF1C

Organism

Homo sapiens (human)

External Links

NCBI Gene

10749

PubChem

10749

Alliance of Genome Resources

HGNC:6317

Annotation

Keyword

3D-structure
ATP-binding
Coiled coil
Cytoskeleton
Disease variant
Methylation
Microtubule
Motor protein
Neurodegeneration
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O43896

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	TAS	9685376
vesicle-mediated transport	IBA
anterograde neuronal dense core vesicle transport	ISS
retrograde neuronal dense core vesicle transport	ISS
retrograde neuronal dense core vesicle transport	IBA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde neuronal dense core vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

vesicle-mediated transport

Golgi vesicle transport [inference]

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

cellular localization [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde neuronal dense core vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

dense core granule cytoskeletal transport [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

Golgi vesicle transport [inference]

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde neuronal dense core vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

dense core granule cytoskeletal transport [inference]

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde neuronal dense core vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

establishment of localization in cell [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde neuronal dense core vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

dense core granule cytoskeletal transport [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

dense core granule cytoskeletal transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

dense core granule cytoskeletal transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

organelle localization [inference]

vesicle localization [inference]

secretory granule localization [inference]

dense core granule localization [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

dense core granule cytoskeletal transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

dense core granule cytoskeletal transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

cellular localization [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde neuronal dense core vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

dense core granule cytoskeletal transport [inference]

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
endoplasmic reticulum	TAS	9685376
Golgi apparatus	TAS	9685376
kinesin complex	IBA
microtubule	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

kinesin complex

cellular anatomical entity [inference]

cytoplasm

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

axon cytoplasm

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
cytoskeletal motor activity	TAS	9685376
protein binding	IPI	10559254 20360680 21988832 24482476 28514442 33961781 35271311 36931259
ATP binding	IEA
microtubule binding	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity

microtubule motor activity [inference]

plus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity [inference]

plus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinesin

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
cytoskeletal motor activity
microtubule binding
microtubule-based movement
nucleotide binding

Displaying **all 5** entries
InterPro
Kinesin motor domain superfamily
Kinesin motor domain, conserved site
Kinesin motor domain
Kinesin-like protein
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050941	spastic ataxia 2	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 43 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10749	Xenbase:XB-GENE-997155
Mus musculus	16562	Xenbase:XB-GENE-997155	MOUSE06834
Drosophila melanogaster	23095	FB:FBgn0267002
Rattus norvegicus	113886		RATNO00354
Macaca mulatta	721601		MACMU14752
Ornithorhynchus anatinus	100088646		ORNAN32292
Pongo abelii	100171679		PONAB13041
Oryctolagus cuniculus	100344759		RABIT07261
Callithrix jacchus	100395818		CALJA33619
Nomascus leucogenys	100590824		NOMLE16102

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Acknowledgements