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IQ motif containing GTPase activating protein 2

Summary

Gene Symbol

IQGAP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10788

PubChem

10788

Alliance of Genome Resources

HGNC:6111

Annotation

Keyword

3D-structure
Alternative splicing
Calmodulin-binding
Coiled coil
Direct protein sequencing
Phosphoprotein
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q13576
B7Z7U6
Q59HA3
B7Z7X2
F5H7S7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
signal transduction	TAS	8756646
regulation of actin cytoskeleton organization	IDA	12515716
Arp2/3 complex-mediated actin nucleation	IDA	12515716
thrombin-activated receptor signaling pathway	IDA	12515716
mitotic actomyosin contractile ring assembly actin filament organization	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway [inference]

thrombin-activated receptor signaling pathway

cell cycle process [inference]

mitotic cell cycle process [inference]

mitotic actomyosin contractile ring assembly actin filament organization

actomyosin contractile ring assembly actin filament organization [inference]

mitotic actomyosin contractile ring assembly actin filament organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization [inference]

actin nucleation [inference]

Arp2/3 complex-mediated actin nucleation

actomyosin contractile ring assembly actin filament organization [inference]

mitotic actomyosin contractile ring assembly actin filament organization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway [inference]

thrombin-activated receptor signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	12515716
cytosol	TAS
microtubule	IDA	21525035
plasma membrane	TAS
microvillus	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell cortex

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

actin-based cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
actin binding	TAS	8756646
GTPase inhibitor activity	TAS	8756646
GTPase activator activity	IBA
calmodulin binding	IBA
calmodulin binding	IPI	21299499

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

calmodulin binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

protein-containing complex binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

GTPase inhibitor activity

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

GTPase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ras GTPase-activating-like protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
actin filament binding
calmodulin binding
mitotic actomyosin contractile ring assembly actin filament organization

Displaying **all 6** entries
InterPro
CH domain superfamily
Calponin homology domain
IQ motif, EF-hand binding site
Ras GTPase-activating domain
RasGAP protein, C-terminal
Rho GTPase activation protein

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	8826	SGD:S000006163
Xenopus tropicalis	10788	Xenbase:XB-GENE-5752023
Saccharomyces cerevisiae S288C	29875	SGD:S000006163
Saccharomyces cerevisiae S288C	128239	SGD:S000006163
Saccharomyces cerevisiae S288C	404710	SGD:S000006163
Pan troglodytes	461801		PANTR35276
Canis lupus familiaris	479177		CANLF11941
Mus musculus	544963		MOUSE11955
Danio rerio	563030		DANRE37072
Macaca mulatta	712026		MACMU38535

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements