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Submissions

methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase

Summary

Gene Symbol

Mthfd1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

108156

PubChem

108156

Alliance of Genome Resources

MGI:1342005

Annotation

Keyword

ATP-binding
Acetylation
Cytoplasm
Direct protein sequencing
Histidine biosynthesis
Hydrolase
Ligase
Methionine biosynthesis
Multifunctional enzyme
NADP
One-carbon metabolism
Oxidoreductase
Phosphoprotein
Purine biosynthesis
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8BXX7
Q922D8
Q3TW74

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
one-carbon metabolic process	ISO
methionine biosynthetic process	IEA ISO
tetrahydrofolate interconversion	IBA IEA IMP ISO	23704330
10-formyltetrahydrofolate biosynthetic process	IMP ISO	23704330
transsulfuration	IMP	23190757

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

one-carbon metabolic process

tetrahydrofolate interconversion

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

one-carbon metabolic process

tetrahydrofolate interconversion

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

one-carbon metabolic process

tetrahydrofolate interconversion

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

somite development

animal organ development [inference]

heart development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IBA IEA ISO
mitochondrion	HDA	14651853 18614015

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
methylenetetrahydrofolate dehydrogenase (NAD+) activity	IDA	23704330
methylenetetrahydrofolate dehydrogenase (NADP+) activity	IBA IMP ISO	15611115
methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	ISO
formate-tetrahydrofolate ligase activity	IMP ISO	15611115 23704330

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH group of donors [inference]

oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [inference]

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [inference]

cyclohydrolase activity [inference]

methenyltetrahydrofolate cyclohydrolase activity

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

formate-tetrahydrofolate ligase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

C-1-tetrahydrofolate synthase, cytoplasmic

Functional Category

F: Nucleotide transport and metabolism
H: Coenzyme transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
catalytic activity
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
tetrahydrofolate interconversion

Displaying **all 9** entries
InterPro
Aminoacid dehydrogenase-like, N-terminal domain superfamily
Formate-tetrahydrofolate ligase, FTHFS, conserved site
Formate-tetrahydrofolate ligase, FTHFS
NAD(P)-binding domain superfamily
P-loop containing nucleoside triphosphate hydrolase
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
Tetrahydrofolate dehydrogenase/cyclohydrolase

Rhea

RHEA:20221

formate + ATP + (6S)-5,6,7,8-tetrahydrofolate

(6R)-10-formyltetrahydrofolate + phosphate + ADP

Enzyme

6.3.4.3

PMID

RHEA:23700

H₂O + (6R)-5,10-methenyltetrahydrofolate

H⁺ + (6R)-10-formyltetrahydrofolate

Enzyme

3.5.4.9

PMID

13672973

RHEA:22812

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP⁺

(6R)-5,10-methenyltetrahydrofolate + NADPH

Enzyme

1.5.1.5

PMID

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0080016	spina bifida	Alliance of Genome Resources
DOID:0080074	neural tube defect	Alliance of Genome Resources
DOID:0080633	developmental cardiac valvular defect	Alliance of Genome Resources
DOID:14250	Down syndrome	Alliance of Genome Resources
DOID:6419	tetralogy of Fallot	Alliance of Genome Resources
DOID:674	cleft palate	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources
DOID:9296	cleft lip	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **112** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4522		HGNC:7432	HUMAN19779
Drosophila melanogaster	41279		FB:FBgn0020385
Rattus norvegicus	64300	10116_1:0024e0	RGD:708531	RATNO36666
Danio rerio	260441		ZFIN:ZDB-GENE-020905-4	DANRE12930
Sus scrofa	414382			PIGXX32673
Pan troglodytes	452965			PANTR08945
Xenopus tropicalis	493369		Xenbase:XB-GENE-992132
Bos taurus	534382			BOVIN01543
Danio rerio	567587		ZFIN:ZDB-GENE-041001-127
Rattus norvegicus	680432		RGD:1591768	RATNO36666

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements