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fibroblast growth factor receptor substrate 2

Summary

Gene Symbol

FRS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10818

PubChem

10818

Alliance of Genome Resources

HGNC:16971

Annotation

Keyword

3D-structure
Membrane
Myristate
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8WU20	FGFR-signaling adaptor SNT Suc1-associated neurotrophic factor target 1
L7RTG7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
gastrulation with mouth forming second	IEA
organ induction	IEA
ventricular septum development	IEA
transmembrane receptor protein tyrosine phosphatase signaling pathway	TAS	9660748
G protein-coupled receptor signaling pathway	TAS	9660748

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

transmembrane receptor protein tyrosine phosphatase signaling pathway

G protein-coupled receptor signaling pathway

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

lens fiber cell development

reproductive process [inference]

developmental process involved in reproduction [inference]

prostate gland epithelium morphogenesis [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

pattern specification process [inference]

axis specification [inference]

embryonic axis specification [inference]

anterior/posterior axis specification, embryo

anterior/posterior axis specification [inference]

anterior/posterior axis specification, embryo

embryonic pattern specification [inference]

embryonic axis specification [inference]

anterior/posterior axis specification, embryo

developmental process [inference]

developmental process involved in reproduction [inference]

prostate gland epithelium morphogenesis [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

embryonic morphogenesis [inference]

gastrulation [inference]

gastrulation with mouth forming second

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

prostate gland epithelium morphogenesis [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

morphogenesis of a branching epithelium [inference]

branching involved in prostate gland morphogenesis [inference]

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

developmental induction [inference]

organ induction

anatomical structure formation involved in morphogenesis [inference]

ectodermal placode formation [inference]

lens placode formation [inference]

lens placode formation involved in camera-type eye formation

anatomical structure development [inference]

cardiac septum development [inference]

ventricular septum development

forebrain development

cell development [inference]

epithelial cell development [inference]

lens fiber cell development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

lens fiber cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of developmental process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction

positive regulation of multicellular organismal process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of animal organ formation [inference]

organ induction

positive regulation of animal organ morphogenesis [inference]

organ induction

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of striated muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiocyte differentiation [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

transmembrane receptor protein tyrosine phosphatase signaling pathway

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of epithelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of striated muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiocyte differentiation [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction

negative regulation of multicellular organismal process [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytosol	TAS
plasma membrane	TAS	9660748
cell-cell junction	IBA
adherens junction	IDA	25468996

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

adherens junction

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase adaptor activity	TAS	9660748
transmembrane receptor protein tyrosine kinase adaptor activity	IBA
fibroblast growth factor receptor binding	IBA
fibroblast growth factor receptor binding	IPI	9660748
neurotrophin TRKA receptor binding	IPI	15488758

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

neurotrophin receptor binding [inference]

neurotrophin TRK receptor binding [inference]

neurotrophin TRKA receptor binding

receptor tyrosine kinase binding [inference]

transmembrane receptor protein tyrosine kinase adaptor activity

growth factor receptor binding [inference]

fibroblast growth factor receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding [inference]

transmembrane receptor protein tyrosine kinase adaptor activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

signaling receptor complex adaptor activity [inference]

transmembrane receptor protein tyrosine kinase adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fibroblast growth factor receptor

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
fibroblast growth factor receptor signaling pathway

Displaying **all 3** entries
InterPro
FRS2, PTB domain
IRS-type PTB domain
PH-like domain superfamily

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	10817	FB:FBgn0032042
Xenopus tropicalis	10818	Xenbase:XB-GENE-479760
Xenopus tropicalis	56552	Xenbase:XB-GENE-479760
Drosophila melanogaster	107971	FB:FBgn0032042
Rattus norvegicus	314850		RATNO37844
Mus musculus	327826	Xenbase:XB-GENE-479760	MOUSE00018
Pan troglodytes	467064		PANTR06378
Canis lupus familiaris	474444		CANLF01413
Bos taurus	538624		BOVIN29428
Danio rerio	559479		DANRE33495

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Acknowledgements