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Guidelines

MIRAGE

integrin alpha 1

Summary

Gene Symbol

Itga1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

109700

PubChem

109700

Alliance of Genome Resources

MGI:96599

Annotation

Keyword

Calcium
Cell adhesion
Disulfide bond
Glycoprotein
Integrin
Magnesium
Metal-binding
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3V3R4	CD49 antigen-like family member A Laminin and collagen receptor VLA-1
Q8BPT3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
cell adhesion	IMP	10528208
cell-matrix adhesion	ISO
cell-matrix adhesion	IBA
cell-matrix adhesion	IEA
integrin-mediated signaling pathway	IBA

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of hydrolase activity [inference]

regulation of phosphatase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of hydrolase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	ISO
acrosomal vesicle	IEA
plasma membrane	TAS
focal adhesion	ISO
focal adhesion	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alpha1-beta1 complex

protein complex involved in cell adhesion [inference]

integrin complex

integrin alpha1-beta1 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alpha1-beta1 complex

cellular anatomical entity [inference]

cell surface

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

basal part of cell

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	ISO
signaling receptor binding	IEA
integrin binding	IBA
protein binding	IPI	11470831 11546798 17377534
collagen binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

integrin binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

cell adhesion molecule binding [inference]

integrin binding

cell adhesion mediator activity [inference]

cell-matrix adhesion mediator activity [inference]

collagen binding involved in cell-matrix adhesion

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

collagen binding

collagen binding involved in cell-matrix adhesion

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

integrin alpha-1

Functional Category

E: Amino acid transport and metabolism
K: Transcription
L: Replication, recombination and repair

Displaying **all 5** entries
Gene Ontology
cell adhesion mediated by integrin
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway
metal ion binding

Displaying entries **1 - 10** of 11 in total

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InterPro
FG-GAP repeat
Integrin alpha beta-propellor
Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Integrin alpha chain
Integrin alpha, N-terminal
Integrin alpha, first immunoglubulin-like domain
Integrin alpha, second immunoglobulin-like domain
Integrin alpha, third immunoglobulin-like domain
Integrin domain superfamily
von Willebrand factor A-like domain superfamily

Ortholog

Displaying entries **31 - 40** of 94 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Sus scrofa	100512142		PIGXX10583
Nomascus leucogenys	100587675		NOMLE34624
Loxodonta africana	100674420		LOXAF16710
Oreochromis niloticus	100697706		ORENI68218
Cavia porcellus	100729544		CAVPO13275
Cricetulus griseus	100750393		CRIGR09763
Otolemur garnettii	100940990		OTOGA18013
Pan paniscus	100978092		PANPA32012
Papio anubis	101013799		PAPAN31132
Saimiri boliviensis boliviensis	101041823		SAIBB09974

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Last updated: April 7, 2025