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dynein, axonemal, heavy chain 5

Summary

Gene Symbol

Dnah5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

110082

PubChem

110082

Alliance of Genome Resources

MGI:107718

Annotation

Keyword

ATP-binding
Cilium
Coiled coil
Cytoskeleton
Dynein
Microtubule
Motor protein
Primary ciliary dyskinesia
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8VHE6	Axonemal beta dynein heavy chain 5 Ciliary dynein heavy chain 5

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cilium movement involved in cell motility	IBA
establishment of localization in cell	IMP	28289722
lateral ventricle development	IMP	11912187
epithelial cilium movement involved in extracellular fluid movement	IMP	28289722
heart development	IMP	25807483

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement

epithelial cilium movement involved in extracellular fluid movement

cilium movement involved in cell motility

flagellated sperm motility

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

outer dynein arm assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

outer dynein arm assembly

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

multicellular organismal process [inference]

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

developmental process [inference]

anatomical structure development [inference]

lateral ventricle development

animal organ development [inference]

heart development

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement

establishment of localization in cell

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GO Term	Evidence Code	PMID
microtubule	IEA
9+2 motile cilium	IBA IDA	23525783 33347437
9+0 motile cilium	IDA	33347437
motile cilium	ISO ISS
extracellular region	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

dynein complex [inference]

axonemal dynein complex

outer dynein arm

catalytic complex [inference]

dynein complex [inference]

axonemal dynein complex

outer dynein arm

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

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GO Term	Evidence Code	PMID
minus-end-directed microtubule motor activity	IBA IEA
protein binding	IPI	29916806
dynein intermediate chain binding	IBA IEA
ATP hydrolysis activity	IEA
dynein light intermediate chain binding	IBA IEA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity

minus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity

minus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Dynein heavy chain

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
dynein intermediate chain binding
dynein light intermediate chain binding
microtubule-based movement
minus-end-directed microtubule motor activity
nucleotide binding

Displaying **all 5** entries
InterPro
Dynein heavy chain AAA lid domain
Dynein heavy chain region D6 P-loop domain
Dynein heavy chain, ATP-binding dynein motor region
Dynein heavy chain, C-terminal domain
Dynein heavy chain, coiled coil stalk

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050144	Kartagener syndrome	Alliance of Genome Resources
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:0110599	primary ciliary dyskinesia 3	Alliance of Genome Resources
DOID:10754	otitis media	Alliance of Genome Resources
DOID:6419	tetralogy of Fallot	Alliance of Genome Resources
DOID:9562	primary ciliary dyskinesia	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1767		HGNC:2950	HUMAN78641
Rattus norvegicus	294854	10116_1:000ccc	RGD:1560828	RATNO22989
Pan troglodytes	461726			PANTR35063
Canis lupus familiaris	606983			CANLF13430
Macaca mulatta	717339			MACMU38260
Drosophila melanogaster	26067053		FB:FBgn0267432
Monodelphis domestica	100020164			MONDO17407
Equus caballus	100070308			HORSE20541
Ornithorhynchus anatinus	100089977			ORNAN30798
Ciona intestinalis	100184836			CIOIN13699

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements