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Rap1 GTPase-activating protein

Summary

Gene Symbol

Rap1gap

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

110351

PubChem

110351

Alliance of Genome Resources

MGI:109338

Annotation

Keyword

Alternative splicing
GTPase activation
Golgi apparatus
Membrane
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A2ALS5	ARPP-90
A2ALS4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
negative regulation of microvillus assembly	ISO
negative regulation of neuron differentiation	ISO
positive regulation of phagocytosis	IMP	24803656
regulation of GTPase activity	ISO
phagocytosis	IMP	24803656

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to glial cell derived neurotrophic factor

response to glial cell derived neurotrophic factor [inference]

cellular response to glial cell derived neurotrophic factor

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to glial cell derived neurotrophic factor

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of thyroid gland epithelial cell proliferation

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of microvillus assembly

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

negative regulation of thyroid gland epithelial cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of thyroid gland epithelial cell proliferation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

regulation of neuron differentiation [inference]

negative regulation of neuron differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

negative regulation of thyroid gland epithelial cell proliferation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of thyroid gland epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of thyroid gland epithelial cell proliferation

regulation of thyroid gland epithelial cell proliferation [inference]

negative regulation of thyroid gland epithelial cell proliferation

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of microvillus assembly [inference]

negative regulation of microvillus assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of microvillus assembly

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

regulation of neuron differentiation [inference]

negative regulation of neuron differentiation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of thyroid gland epithelial cell proliferation

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of microvillus assembly

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of microvillus assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of microvillus assembly [inference]

negative regulation of microvillus assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of microvillus assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of microvillus organization [inference]

regulation of microvillus assembly [inference]

negative regulation of microvillus assembly

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of microvillus assembly [inference]

negative regulation of microvillus assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of microvillus assembly

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of microvillus assembly

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of thyroid gland epithelial cell proliferation

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
membrane	IBA ISO
early endosome	ISO
neuronal cell body	ISO
dendrite	ISO
Golgi membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

cell body [inference]

neuronal cell body

Displaying **all 4** entries
GO Term	Evidence Code	PMID
GTPase activator activity	IBA IEA ISO
protein binding	IPI	24803656
small GTPase binding	ISO
protein homodimerization activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

rap1 GTPase-activating protein 1 isoform 1

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
regulation of small GTPase mediated signal transduction

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050908	myelodysplastic syndrome	Alliance of Genome Resources
DOID:1312	focal segmental glomerulosclerosis	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:1909	melanoma	Alliance of Genome Resources
DOID:3312	bipolar disorder	Alliance of Genome Resources
DOID:3969	thyroid gland papillary carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 94 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Callithrix jacchus	100402248			CALJA40056
Ailuropoda melanoleuca	100467326			AILME12464
Danio rerio	100538309		ZFIN:ZDB-GENE-131119-39
Nomascus leucogenys	100602986			NOMLE23065
Sus scrofa	100627043			PIGXX29234
Loxodonta africana	100669202			LOXAF11278
Oreochromis niloticus	100704397			ORENI36525
Cavia porcellus	100725658	10141_0:002ab2		CAVPO11930
Cricetulus griseus	100764361	10029_0:00126b		CRIGR11648
Sarcophilus harrisii	100927076			SARHA14095