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chromodomain helicase DNA binding protein 1

Summary

Gene Symbol

CHD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

1105

PubChem

1105

Alliance of Genome Resources

HGNC:1915

Annotation

Keyword

3D-structure
Alternative splicing
Chromatin regulator
Cytoplasm
DNA-binding
Disease variant
Helicase
Intellectual disability
Nucleus
Phosphoprotein
Reference proteome
Repeat
Transcription regulation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B3KT33
O14646	ATP-dependent helicase CHD1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
positive regulation by host of viral transcription	IMP	25297984
chromatin remodeling	IMP	28866611
nucleosome organization	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

nucleosome organization

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

positive regulation by host of viral transcription

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nuclear chromosome	IDA	9326634
nucleoplasm	TAS
chromatin	IBA
nucleus	IBA IDA	22046413
cytoplasm	IDA	22046413

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

nuclear chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

nuclear chromosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	22419161 26751641 32814053
DNA binding	IBA
ATP-dependent chromatin remodeler activity	IBA
chromatin binding	IBA
helicase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

ATP-dependent chromatin remodeler activity

binding [inference]

protein binding

histone binding

methylated histone binding

modification-dependent protein binding [inference]

methylation-dependent protein binding [inference]

methylated histone binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity

ATP-dependent activity, acting on DNA [inference]

ATP-dependent chromatin remodeler activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

CHROMODOMAIN HELICASE DNA BINDING

Functional Category

I: Lipid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
chromatin binding
histone binding
hydrolase activity
nucleotide binding

Displaying **all 6** entries
InterPro
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
P-loop containing nucleoside triphosphate hydrolase
SNF2, N-terminal
SNF2-like, N-terminal domain superfamily
SNF2/RAD5-like, C-terminal helicase domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0080909	castration-resistant prostate carcinoma	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12648		MGI:88393	MOUSE21777
Drosophila melanogaster	33505		FB:FBgn0250786
Caenorhabditis elegans	172432		WB:WBGene00010369
Rattus norvegicus	308215		RGD:1306794	RATNO17069
Pan troglodytes	461968	9598_0:0018cb		PANTR35842
Canis lupus familiaris	488891			CANLF11856
Bos taurus	505123			BOVIN34027
Danio rerio	563236		ZFIN:ZDB-GENE-030131-7120	DANRE00993
Macaca mulatta	702070			MACMU38897
Xenopus laevis	733207		Xenbase:XB-GENE-960482

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024