GlyCosmos Portal

Submissions

citron rho-interacting serine/threonine kinase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

11113

PubChem

11113

Alliance of Genome Resources

HGNC:1985

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Coiled coil
Cytoplasm
Developmental protein
Differentiation
Disease variant
Mitosis
Neurogenesis
Phosphoprotein
Primary microcephaly
Reference proteome
SH3-binding
Serine/threonine-protein kinase
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
O14578	Serine/threonine-protein kinase 21

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
negative regulation of hippo signaling	IMP	30865227
mitotic cytokinesis	IMP	16236794 27453578
mitotic cell cycle	ISS	11086988
generation of neurons	ISS	11086988
protein phosphorylation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cell cycle [inference]

mitotic cell cycle

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

mitotic cell cycle process [inference]

mitotic cytokinesis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis [inference]

generation of neurons

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis [inference]

generation of neurons

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of cell division [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
cytosol	IDA TAS	30865227

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 12 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
protein binding	IPI	16431929
protein serine kinase activity	IEA
SH3 domain binding	IEA
metal ion binding	IEA
protein serine/threonine kinase activity	ISS	9792683

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

binding [inference]

protein binding

transcription factor binding [inference]

transcription coregulator binding [inference]

transcription coactivator binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein domain specific binding [inference]

scaffold protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

kinase regulator activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

protein kinase regulator activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

citron Rho-interacting kinase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 8** entries
Gene Ontology
ATP binding
actomyosin structure organization
kinase activity
metal ion binding
mitotic cytokinesis
nucleotide binding
phosphorylation
transferase activity

Displaying 1 entry
InterPro
Citron homology (CNH) domain

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0070288	primary autosomal recessive microcephaly 17	Alliance of Genome Resources
DOID:0070297	primary microcephaly	Alliance of Genome Resources
DOID:0081292	traumatic brain injury	Alliance of Genome Resources
DOID:10907	microcephaly	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 17 in total

1

2

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12704		MGI:105313
Drosophila melanogaster	39429		FB:FBgn0002466
Rattus norvegicus	83620		RGD:70878
Caenorhabditis elegans	173864		WB:WBGene00019087
Xenopus tropicalis	100145758		Xenbase:XB-GENE-981097
Danio rerio	100329792		ZFIN:ZDB-GENE-130530-981
Pongo abelii	100443427	9601_0:00352a
Pan paniscus	100974320	9597_0:003752
Felis catus	101094297			FELCA27761
Gorilla gorilla gorilla	101126596	9595_0:003892