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kinesin family member 3A

Summary

Gene Symbol

KIF3A

Organism

Homo sapiens (human)

External Links

NCBI Gene

11127

PubChem

11127

Alliance of Genome Resources

HGNC:6319

Annotation

Keyword

ATP-binding
Cilium
Cilium biogenesis/degradation
Coiled coil
Cytoskeleton
Microtubule
Motor protein
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q9Y496	Microtubule plus end-directed kinesin motor 3A
B4DHG8
J3KPF9
Q05CT3
E9PES4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein localization to cell junction	IMP	24338362
protein transport	IMP	24338362
centriole-centriole cohesion	ISS
anterograde axonal transport	IBA
cilium assembly	IBA ISS

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule anchoring [inference]

microtubule anchoring at microtubule organizing center [inference]

microtubule anchoring at centrosome

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

plus-end-directed organelle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

cell cycle process [inference]

centriole-centriole cohesion

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

plus-end-directed organelle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

protein localization to cell junction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule anchoring [inference]

microtubule anchoring at microtubule organizing center [inference]

microtubule anchoring at centrosome

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

protein localization to cell junction

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

plus-end-directed organelle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

plus-end-directed organelle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

plus-end-directed organelle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

plus-end-directed organelle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

plus-end-directed organelle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

plus-end-directed organelle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

plus-end-directed vesicle transport along microtubule

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

protein localization to cell junction

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
microtubule	IBA
kinesin II complex	IDA	16298999
ciliary tip	TAS
kinesin complex	IBA
centriole	IDA	23386061

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

kinesin complex

kinesin II complex

cellular anatomical entity [inference]

cytoplasm

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

axon cytoplasm

microtubule organizing center [inference]

centrosome

cytosol

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

cytoskeleton [inference]

microtubule cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

ciliary tip

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

spindle microtubule

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16298999 17043677 19934039 20643351 22261744 24338362 24591568 26496610 27173435 28514442 31413325 33961781 35271311
spectrin binding	IDA	23704327
small GTPase binding	IPI	26021297
ATP hydrolysis activity	IBA
plus-end-directed microtubule motor activity	TAS	16298999

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity

plus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

spectrin binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

GTPase binding [inference]

small GTPase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

spectrin binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity

plus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kinesin

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
cytoskeletal motor activity
microtubule binding
microtubule-based movement
nucleotide binding

Displaying **all 5** entries
InterPro
Kinesin motor domain superfamily
Kinesin motor domain, conserved site
Kinesin motor domain
Kinesin-like protein
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080322	polycystic kidney disease	Alliance of Genome Resources
DOID:10325	silicosis	Alliance of Genome Resources
DOID:1934	dysostosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16568		MGI:107689	MOUSE05245
Drosophila melanogaster	38611		FB:FBgn0004380
Rattus norvegicus	84392		RGD:621536	RATNO03211
Xenopus laevis	399401		Xenbase:XB-GENE-986468
Pan troglodytes	450168	9598_0:0016e8		PANTR36133
Canis lupus familiaris	474675			CANLF02093
Bos taurus	541246			BOVIN33010
Danio rerio	550267		ZFIN:ZDB-GENE-050417-71	DANRE07733
Macaca mulatta	574270			MACMU38322
Caenorhabditis elegans	3565057		WB:WBGene00002230