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chromogranin A

Summary

Gene Symbol

CHGA

Aliases

PHE5
PHES
pancreastatin
parastatin
parathyroid secretory protein 1
vasostatin

Organism

Homo sapiens (human)

External Links

NCBI Gene

1113

HGNC

1929

KEGG Gene ID

hsa:1113

PubChem

1113

Alliance of Genome Resources

HGNC:1929

Annotation

Keyword

3D-structure
Amidation
Antibiotic
Calcium
Cleavage on pair of basic residues
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Fungicide
Oxidation
Phosphoprotein
Proteoglycan
Proteomics identification
Reference proteome
Secreted
Signal
Sulfation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
G5E968
P10645	Pituitary secretory protein I
Q86T07

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
defense response to fungus	IEA
regulation of the force of heart contraction	ISS
negative regulation of insulin secretion	IBA
defense response to Gram-negative bacterium	IDA	15723172
killing of cells of another organism	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte degranulation [inference]

mast cell degranulation

immune response [inference]

innate immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

mast cell activation

leukocyte migration [inference]

leukocyte chemotaxis [inference]

mast cell chemotaxis

myeloid leukocyte migration [inference]

mast cell migration [inference]

mast cell chemotaxis

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

mast cell activation

cell killing [inference]

killing of cells of another organism

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

G protein-coupled receptor signaling pathway involved in heart process [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

mast cell chemotaxis

myeloid leukocyte migration [inference]

mast cell migration [inference]

mast cell chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

mast cell chemotaxis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

mast cell activation

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

mast cell chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

defense response to fungus

defense response to other organism [inference]

defense response to bacterium

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

defense response to fungus

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

response to fungus [inference]

defense response to fungus

defense response to other organism [inference]

defense response to bacterium

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

establishment of localization in cell [inference]

leukocyte degranulation [inference]

mast cell degranulation

establishment of organelle localization [inference]

mast cell degranulation

organelle localization [inference]

establishment of organelle localization [inference]

mast cell degranulation

vacuolar localization [inference]

lysosome localization [inference]

mast cell degranulation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to secretory granule

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of catecholamine secretion [inference]

negative regulation of catecholamine secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

negative regulation of catecholamine secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cellular component biogenesis [inference]

positive regulation of dense core granule biogenesis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of relaxation of muscle [inference]

positive regulation of relaxation of cardiac muscle

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

G protein-coupled receptor signaling pathway involved in heart process [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

regulation of phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of dense core granule biogenesis

regulation of dense core granule biogenesis [inference]

positive regulation of dense core granule biogenesis

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cellular component biogenesis [inference]

positive regulation of dense core granule biogenesis

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of catecholamine secretion [inference]

negative regulation of catecholamine secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

regulation of relaxation of muscle [inference]

positive regulation of relaxation of muscle [inference]

positive regulation of relaxation of cardiac muscle

regulation of relaxation of cardiac muscle [inference]

positive regulation of relaxation of cardiac muscle

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

regulation of cardiac muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of striated muscle contraction [inference]

positive regulation of cardiac muscle contraction

positive regulation of relaxation of muscle [inference]

positive regulation of relaxation of cardiac muscle

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of cardiac muscle contraction

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

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GO Term	Evidence Code	PMID
perinuclear region of cytoplasm	IDA	20862257
chromaffin granule	IBA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

dense core granule [inference]

neuronal dense core vesicle

chromaffin granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

dense core granule [inference]

neuronal dense core vesicle

chromaffin granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

dense core granule [inference]

neuronal dense core vesicle

chromaffin granule

perinuclear region of cytoplasm

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000100604

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K19990

Name

chromogranin-A

References

Disease

Disease Ontology

Displaying entries **41 - 50** of **139** in total

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DO ID	Disease Name	Source
DOID:1520	colon carcinoma	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1664	pineoblastoma	DisGeNET
DOID:169	neuroendocrine tumor	DisGeNET
DOID:170	endocrine gland cancer	DisGeNET
DOID:171	neuroectodermal tumor	DisGeNET
DOID:1749	squamous cell carcinoma	DisGeNET
DOID:1793	pancreatic cancer	DisGeNET
DOID:1799	islet cell tumor	DisGeNET

Ortholog

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Species	Gene ID	Orthologous MAtrix
Cyprinus carpio carpio	109108865	CYPCA82125
Cyprinus carpio carpio	109113429	CYPCA105084
Corvus moneduloides	116446063	CORMO23120
Carlito syrichta	103275202	CARSF16105
Strigops habroptila	115606891	STRHB09596

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements