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WD repeat domain 45

Summary

Gene Symbol

WDR45

Organism

Homo sapiens (human)

External Links

NCBI Gene

11152

PubChem

11152

Alliance of Genome Resources

HGNC:28912

Annotation

Keyword

Alternative splicing
Autophagy
Cytoplasm
Disease variant
Lipid-binding
Neurodegeneration
Reference proteome
Repeat
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y484	WD repeat-containing protein 45

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein localization to phagophore assembly site	IBA
autophagy	IMP	23435086
autophagy of mitochondrion	IBA
protein lipidation involved in autophagosome assembly	IBA
autophagy of peroxisome	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

catabolic process [inference]

cellular catabolic process [inference]

autophagy

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

macromolecule modification [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

process utilizing autophagic mechanism [inference]

autophagy

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

autophagy of mitochondrion

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

organelle disassembly [inference]

autophagy of mitochondrion

cellular component disassembly [inference]

organelle disassembly [inference]

autophagy of mitochondrion

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of vacuole organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phagophore assembly site	IDA	28561066
phagophore assembly site membrane	IBA
extrinsic component of membrane
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

phagophore assembly site membrane

extrinsic component of membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	20562859 28561066 31412244 33961781 34524948 35271311
phosphatidylinositol-3,5-bisphosphate binding	IBA
protein kinase binding	IPI	28561066
phosphatidylinositol phosphate binding	IDA	28561066
phosphatidylinositol-3-phosphate binding	IBA IDA	31271352

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding

phosphatidylinositol-3-phosphate binding

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Autophagy-related protein

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
nucleophagy
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3-phosphate binding
protein localization to phagophore assembly site

Displaying **all 4** entries
InterPro
PROPPIN
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110739	neurodegeneration with brain iron accumulation 5	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	54636		MGI:1859606	MOUSE65731
Caenorhabditis elegans	189705		WB:WBGene00012641
Rattus norvegicus	302559		RGD:1359718	RATNO44728
Danio rerio	393200		ZFIN:ZDB-GENE-040426-990	DANRE01629
Xenopus laevis	446846		Xenbase:XB-GENE-972383
Pan troglodytes	465626	9598_0:00572d		PANTR45975
Pan troglodytes	473602			PANTR45975
Xenopus tropicalis	496788		Xenbase:XB-GENE-972376
Bos taurus	539190			BOVIN37051
Canis lupus familiaris	612890			CANLF19767

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements