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Guidelines

MIRAGE

ADAM metallopeptidase with thrombospondin type 1 motif 7

Summary

Gene Symbol

ADAMTS7

Organism

Homo sapiens (human)

External Links

NCBI Gene

11173

PubChem

11173

Alliance of Genome Resources

HGNC:223

Annotation

Keyword

Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Extracellular matrix
Metal-binding
Metalloprotease
Proteoglycan
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UFZ4
Q9UKP4	COMPase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
chondrocyte differentiation	IEA
proteoglycan metabolic process	IEA
proteolysis	IBA
extracellular matrix organization	IBA
collagen fibril organization	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis involved in protein catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

multicellular organismal process [inference]

ossification [inference]

ossification involved in bone maturation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to BMP stimulus

response to BMP [inference]

cellular response to BMP stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to BMP stimulus

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

response to interleukin-1 [inference]

cellular response to interleukin-1

cellular response to cytokine stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
endoplasmic reticulum lumen	TAS
cell surface	IEA
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying **all 5** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	IDA	18485748
metalloendopeptidase activity	IBA
protein binding	IPI	18485748
metallopeptidase activity	TAS	10464288
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

thrombospondin

Functional Category

T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 6** entries
Gene Ontology
extracellular matrix organization
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 8** entries
InterPro
ADAMTS, cysteine-rich domain 2
ADAMTS/ADAMTS-like, Spacer 1
ADAMTS/ADAMTS-like, cysteine-rich domain 3
ADAMTS/ADAMTS-like
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	11173	Xenbase:XB-GENE-6037434
Drosophila melanogaster	81792	FB:FBgn0029791
Mus musculus	108153	Xenbase:XB-GENE-6037434	MOUSE62010
Drosophila melanogaster	170691	FB:FBgn0029791
Drosophila melanogaster	170692	FB:FBgn0029791
Drosophila melanogaster	171019	FB:FBgn0029791
Drosophila melanogaster	208936	FB:FBgn0029791
Drosophila melanogaster	239337	FB:FBgn0029791
Drosophila melanogaster	240322	FB:FBgn0029791
Rattus norvegicus	315879	Xenbase:XB-GENE-6037434	RATNO41269

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: April 7, 2025