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chitinase 1

Summary

Gene Symbol

CHIT1

Aliases

CHI3
CHIT
chitotriosidase

Organism

Homo sapiens (human)

External Links

NCBI Gene

1118

HGNC

1936

KEGG Gene ID

hsa:1118

PubChem

1118

Alliance of Genome Resources

HGNC:1936

Annotation

Keyword

3D-structure
Alternative splicing
Chitin degradation
Chitin-binding
Direct protein sequencing
Disulfide bond
Glycoprotein
Glycosidase
Lysosome
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13231	Chitinase-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
polysaccharide digestion	TAS
immune response	NAS	9748235
response to bacterium	TAS	9402970
polysaccharide catabolic process	IEA
chitin catabolic process	IBA IDA TAS	19725875 9748235

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

amino sugar metabolic process [inference]

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

glucosamine-containing compound metabolic process [inference]

chitin metabolic process [inference]

chitin catabolic process

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

chitin metabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process

aminoglycan catabolic process [inference]

chitin catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

amino sugar catabolic process [inference]

glucosamine-containing compound catabolic process [inference]

chitin catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

chitin catabolic process

multicellular organismal process [inference]

digestion [inference]

polysaccharide digestion

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	IBA TAS
extracellular space	IDA	19725875
tertiary granule lumen	TAS
lysosome	IEA
specific granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

tertiary granule lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endochitinase activity	IDA	19725875
chitin binding	IBA TAS	9748235
chitinase activity	IBA IDA TAS	11085997 9748235
hydrolase activity, hydrolyzing O-glycosyl compounds	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

chitinase activity

endochitinase activity

binding [inference]

carbohydrate derivative binding [inference]

chitin binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01183

Name

chitinase [EC:3.2.1.14]

References

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050452	mevalonic aciduria	DisGeNET
DOID:0050461	aspartylglucosaminuria	DisGeNET
DOID:0050848	obstructive sleep apnea	DisGeNET
DOID:0050873	follicular lymphoma	DisGeNET
DOID:0060357	chylomicron retention disease	DisGeNET
DOID:0060672	Grn-related frontotemporal lobar degeneration with Tdp43 inclusions	DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET
DOID:0060895	Parkinson's disease 4	DisGeNET
DOID:0060896	Parkinson's disease 23	DisGeNET

PubChem Disease

MedGen Diseases

Chitotriosidase deficiency

OMIM Phenotypes

CHITOTRIOSIDASE DEFICIENCY; CHITD

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 52 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	180628	WB:WBGene00000503
Drosophila melanogaster	31926	FB:FBgn0026415
Drosophila melanogaster	31935	FB:FBgn0263132
Drosophila melanogaster	34978	FB:FBgn0020416
Drosophila melanogaster	34979	FB:FBgn0020415
Drosophila melanogaster	34981	FB:FBgn0020414
Drosophila melanogaster	36868	FB:FBgn0013763
Drosophila melanogaster	37104	FB:FBgn0064237
Drosophila melanogaster	37390	FB:FBgn0034580
Callorhinchus milii	103182484		CALMI24986

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Tools

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements