GlyCosmos Portal

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cytoplasm
Disease variant
Epilepsy
Intellectual disability
Lipid droplet
Phospholipid biosynthesis
Phosphoprotein
Reference proteome
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
P35790	CHETK-alpha Ethanolamine kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lipid metabolic process		10363580
lipid transport		10363580
phosphatidylethanolamine biosynthetic process	IBA IDA IEA	19915674
CDP-choline pathway	IBA
phosphatidylcholine biosynthetic process	IDA	19915674 34077757

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

primary metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process

CDP-choline pathway

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	IDA TAS	34077757
cytoplasm	IBA
lipid droplet	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ethanolamine kinase activity	IBA IDA	19915674
protein homodimerization activity	IDA	34077757
choline kinase activity	IBA IDA	19915674 34077757
protein tyrosine kinase activity	IEA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

cholinesterase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000110721

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K14156

Name

choline/ethanolamine kinase [EC:2.7.1.32 2.7.1.82]

References

Rhea

RHEA:12837

choline + ATP

H⁺ + phosphocholine + ADP

Enzyme

2.7.1.32

PMID

RHEA:13069

ATP + ethanolamine

H⁺ + ADP + phosphoethanolamine

Enzyme

2.7.1.82

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 91 in total

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DO ID	Disease Name	Source
DOID:0050557	congenital muscular dystrophy	DisGeNET DisGeNET
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0050912	colon adenoma	Alliance of Genome Resources
DOID:0060255	rippling muscle disease 2	DisGeNET
DOID:0060326	myelomeningocele	DisGeNET DisGeNET
DOID:0070247	autosomal dominant Emery-Dreifuss muscular dystrophy 2	DisGeNET
DOID:0080016	spina bifida	DisGeNET
DOID:0080092	myofibrillar myopathy 1	DisGeNET
DOID:0080094	myofibrillar myopathy 3	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 27 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000218	High palate
HP:0000252	Microcephaly
HP:0000639	Nystagmus
HP:0000718	Aggressive behavior
HP:0000729	Autistic behavior
HP:0000752	Hyperactivity
HP:0000787	Nephrolithiasis
HP:0001266	Choreoathetosis
HP:0001276	Hypertonia

Displaying 1 entry
Disease ID	Disease Name
OMIM:620023	neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures

PubChem Disease

MedGen Diseases

Neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures

OMIM Phenotypes

NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, MOVEMENT ABNORMALITIES, AND SEIZURES; NEDMIMS

KEGG Diseases

Neurodevelopmental disorder with microcephaly

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001043
Gene Name: choline kinase alpha

Ortholog

Displaying entries **61 - 65** of 65 in total

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Species	Gene ID	Orthologous MAtrix
Cyprinus carpio carpio	109110126	CYPCA68883
Nannospalax galili	103744530	NANGA23879
Corvus moneduloides	116445919	CORMO22477
Carlito syrichta	103255249	CARSF30621
Strigops habroptila	115607035	STRHB09922

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements