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CHM Rab escort protein

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

1121

PubChem

1121

Alliance of Genome Resources

HGNC:1940

Annotation

Keyword

Alternative splicing
Cytoplasm
Disease variant
GTPase activation
Reference proteome
Transferase
Vision

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P24386	Choroideremia protein Rab escort protein 1 TCD protein
A8K545
B4DRL9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
vesicle-mediated transport	IBA
intracellular protein transport	IEA
visual perception	IEA
protein geranylgeranylation	IDA	7957092
small GTPase mediated signal transduction	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

cellular metabolic process [inference]

prenylation [inference]

protein prenylation [inference]

protein geranylgeranylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

macromolecule modification [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

vesicle-mediated transport

cellular metabolic process [inference]

prenylation [inference]

protein prenylation [inference]

protein geranylgeranylation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane

protein transport [inference]

intracellular protein transport

establishment of protein localization to membrane [inference]

protein targeting to membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Rab-protein geranylgeranyltransferase complex	IBA IDA	7957092
nucleus	IBA
cytosol	IBA IMP TAS	7957092
cytoplasm

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

Rab-protein geranylgeranyltransferase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
GTPase activator activity	IEA
protein binding	IPI	21905166 28514442 33961781 35271311
small GTPase binding	IDA IPI	7957092
Rab geranylgeranyltransferase activity	TAS	8380507
GDP-dissociation inhibitor activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

prenyltransferase activity [inference]

protein prenyltransferase activity [inference]

protein geranylgeranyltransferase activity [inference]

Rab geranylgeranyltransferase activity

catalytic activity, acting on a protein [inference]

protein prenyltransferase activity [inference]

protein geranylgeranyltransferase activity [inference]

Rab geranylgeranyltransferase activity

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Rab proteins geranylgeranyltransferase component

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
GDP-dissociation inhibitor activity
small GTPase-mediated signal transduction

Displaying **all 2** entries
InterPro
FAD/NAD(P)-binding domain superfamily
GDP dissociation inhibitor

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9821	choroideremia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12662		MGI:892979	MOUSE64984
Rattus norvegicus	24942		RGD:2340	RATNO44432
Drosophila melanogaster	37246		FB:FBgn0026378
Caenorhabditis elegans	175311		WB:WBGene00022051
Xenopus laevis	399048		Xenbase:XB-GENE-956392
Danio rerio	402935		ZFIN:ZDB-GENE-030318-2	DANRE21190
Xenopus laevis	446239		Xenbase:XB-GENE-6251709
Pan troglodytes	465737	9598_0:0058ed		PANTR46392
Canis lupus familiaris	480972			CANLF19941
Bos taurus	519552			BOVIN36785