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A-kinase anchoring protein 13

Summary

Gene Symbol

AKAP13

Organism

Homo sapiens (human)

External Links

NCBI Gene

11214

PubChem

11214

Alliance of Genome Resources

HGNC:371

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Cytoplasm
Guanine-nucleotide releasing factor
Kinase
Membrane
Metal-binding
Methylation
Nucleus
Phosphoprotein
Proteomics identification
Proto-oncogene
Reference proteome
Zinc
Zinc-finger

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q12802	AKAP-Lbc Breast cancer nuclear receptor-binding auxiliary protein Guanine nucleotide exchange factor Lbc Human thyroid-anchoring protein 31 Lymphoid blast crisis oncogene Non-oncogenic Rho GTPase-specific GTP exchange factor Protein kinase A-anchoring protein 13 p47
A8MYJ1
B0AZU4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
MAPK cascade	IEA
G protein-coupled receptor signaling pathway	IDA	11546812
heart development	ISS
regulation of Rho protein signal transduction	IBA
positive regulation of Rho protein signal transduction	IDA	11546812

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardiac muscle cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

cardiac muscle cell differentiation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardiac muscle cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

cardiac muscle cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of small GTPase mediated signal transduction

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction

positive regulation of Rho protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of small GTPase mediated signal transduction

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction

positive regulation of Rho protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adrenergic receptor signaling pathway

intracellular signal transduction [inference]

MAPK cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of small GTPase mediated signal transduction

regulation of Ras protein signal transduction [inference]

regulation of Rho protein signal transduction

positive regulation of Rho protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of sarcomere organization

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rho protein signal transduction

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of sarcomere organization

regulation of supramolecular fiber organization [inference]

regulation of sarcomere organization

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
cytosol	TAS
cytosol	IDA	11546812
cell cortex	IDA	11546812
actin cytoskeleton	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
MAP-kinase scaffold activity	IDA	21224381
MAP-kinase scaffold activity	IBA
guanyl-nucleotide exchange factor activity	TAS
guanyl-nucleotide exchange factor activity	IDA	11546812 25186459
protein binding	IPI	15161933 15691829 16301118 21224381 28514442 33961781 35271311 36931259 9627117

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

protein kinase A binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

molecular adaptor activity

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

MAP-kinase scaffold activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

A-kinase anchor protein 13

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
MAP-kinase scaffold activity
adrenergic receptor signaling pathway
metal ion binding
positive regulation of canonical NF-kappaB signal transduction
regulation of Rho protein signal transduction

Displaying **all 7** entries
InterPro
ARHGEF1-like, PH domain
C1-like domain superfamily
Dbl homology (DH) domain superfamily
Dbl homology (DH) domain
PH-like domain superfamily
Pleckstrin homology domain
Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9181	FB:FBgn0032796
Xenopus tropicalis	11214	Xenbase:XB-GENE-983148
Drosophila melanogaster	16800	FB:FBgn0032796
Mus musculus	75547		MOUSE53060
Rattus norvegicus	293024		RATNO17678
Canis lupus familiaris	479032		CANLF12032
Bos taurus	504288		BOVIN16348
Macaca mulatta	698172		MACMU41175
Pan troglodytes	743772		PANTR11068
Ornithorhynchus anatinus	100078722		ORNAN22154