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CHM like Rab escort protein

Summary

Gene Symbol

CHML

Organism

Homo sapiens (human)

External Links

NCBI Gene

1122

PubChem

1122

Alliance of Genome Resources

HGNC:1941

Annotation

Keyword

Cytoplasm
GTPase activation
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P26374	Choroideremia-like protein Rab escort protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
vesicle-mediated transport	IBA
intracellular protein transport	IEA
protein geranylgeranylation	IDA IMP	12356470 15186776
small GTPase mediated signal transduction	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

cellular metabolic process [inference]

prenylation [inference]

protein prenylation [inference]

protein geranylgeranylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

macromolecule modification [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein prenylation [inference]

protein geranylgeranylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

vesicle-mediated transport

cellular metabolic process [inference]

prenylation [inference]

protein prenylation [inference]

protein geranylgeranylation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Rab-protein geranylgeranyltransferase complex	IBA IMP	12356470
nucleoplasm	IDA
nucleus	IBA
cytosol	IBA IDA TAS
cytoplasm

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

Rab-protein geranylgeranyltransferase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
GTPase activator activity	IEA
small GTPase binding	IDA IPI	15186776
GDP-dissociation inhibitor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Rab proteins geranylgeranyltransferase component

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
GDP-dissociation inhibitor activity
small GTPase-mediated signal transduction

Displaying **all 2** entries
InterPro
FAD/NAD(P)-binding domain superfamily
GDP dissociation inhibitor

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:2841	asthma	Alliance of Genome Resources
DOID:9821	choroideremia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 35 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12663		MGI:101913	MOUSE30769
Drosophila melanogaster	37246		FB:FBgn0026378
Caenorhabditis elegans	175311		WB:WBGene00022051
Danio rerio	402935		ZFIN:ZDB-GENE-030318-2	DANRE21190
Bos taurus	532324			BOVIN08167
Rattus norvegicus	689102		RGD:1596201	RATNO06465
Saccharomyces cerevisiae S288C	854552		SGD:S000005897
Pongo abelii	100455814	9601_0:000406
Xenopus tropicalis	100488898		Xenbase:XB-GENE-956389
Sus scrofa	100521677			PIGXX00082

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements